margarita25
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Possible cause explained:
Acute Hepatitis of Unknown Origin Among Children - 21 April 2022
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anneg
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This article is related to the information in the video by John Campbell @margarita25 posted above:
New studies offer theory on cause of unusual hepatitis cases in kids
There is a new theory about what may be causing puzzling cases of pediatric hepatitis of unknown origin — and it is complex.
Two new and as-yet-unpublished studies from scientists in the United Kingdom theorize that children who have developed the hepatitis cases may have been co-infected with two different viruses and had a genetic predisposition to have an over-exuberant immune response when that happened....
Previously the leading hypothesis was that adenovirus 41, which had been found in a number of the infected children, was causing the liver damage. Adenovirus 41 has been known to trigger liver damage in immunocompromised children, but had never been seen to do so in children with intact immune systems.
But the new studies report finding the presence of something called adeno-associated virus 2 — AAV2 for short — in the blood and in liver tissues from a number of affected children. They also found the children were infected with adenoviruses or herpes viruses.
[...]
More than 1,000 such cases from 35 countries have been reported to the World Health Organization. Of that total, 22 children have died and 46 have needed liver transplants. In the United States, 355 possible cases are under investigation, the Centers for Disease Control and Prevention says. As of late June, 20 of those children had required liver transplants and 11 had died.
The studies also suggested that the disruption of normal life triggered by the pandemic may have contributed to increased transmission of adeno-associated virus 2 and adenoviruses when Covid-19 control measures started to ease, because more children would have been susceptible to them. That, in turn, would have led to an increased number of cases of hepatitis in children....
New studies offer theory on cause of unusual hepatitis cases in kids
New studies offer theory on cause of unusual hepatitis cases in kids
By Helen Branswell July 25, 2022There is a new theory about what may be causing puzzling cases of pediatric hepatitis of unknown origin — and it is complex.
Two new and as-yet-unpublished studies from scientists in the United Kingdom theorize that children who have developed the hepatitis cases may have been co-infected with two different viruses and had a genetic predisposition to have an over-exuberant immune response when that happened....
Previously the leading hypothesis was that adenovirus 41, which had been found in a number of the infected children, was causing the liver damage. Adenovirus 41 has been known to trigger liver damage in immunocompromised children, but had never been seen to do so in children with intact immune systems.
But the new studies report finding the presence of something called adeno-associated virus 2 — AAV2 for short — in the blood and in liver tissues from a number of affected children. They also found the children were infected with adenoviruses or herpes viruses.
[...]
More than 1,000 such cases from 35 countries have been reported to the World Health Organization. Of that total, 22 children have died and 46 have needed liver transplants. In the United States, 355 possible cases are under investigation, the Centers for Disease Control and Prevention says. As of late June, 20 of those children had required liver transplants and 11 had died.
The studies also suggested that the disruption of normal life triggered by the pandemic may have contributed to increased transmission of adeno-associated virus 2 and adenoviruses when Covid-19 control measures started to ease, because more children would have been susceptible to them. That, in turn, would have led to an increased number of cases of hepatitis in children....