One possibility just hit me that would account for several places she was supposed to be. If she started out going east on W. Pershing around 7:30, the guy there would probably be right about seeing her then, later when she was getting closer to the end of her run, she may have been running west on 2nd Street, so the guy there would be right about her passing there. If she continued on 2nd and then turned on 385th, she would probably have passed by the neighbor's house where LE told him she had passed but he hadn't seen here. Once she got back to the house, she may have just stopped running and started walking to her mother's house to eat, get the car and her clothes for the next day; that would account for the witness on W. Des Moines seeing her walk by toward Jackson. That would mean she was probably picked up on Jackson, taken to Hwy 6 and east to the NE area of interest. Did I miss much in that?
ETA: Running on 2nd Street would also have brought her past Casey's.