Multisystem inflammatory syndrome in children (MIS-C and COVID-19)

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MIS-C: Some children's hospitals see a surge in rare Covid-19 complication - CNN
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Doctors don't know what causes it. Often kids have Covid-19 first, but not always. The novel coronavirus doesn't usually cause severe disease in children, but for those few kids that do go on to develop MIS-C, the condition seems to inflame different parts of the body, and it can be serious.
What doctors do know is that various children's hospitals around the country have reported seeing a higher number of cases these past few months, even though MIS-C is considered rare.

In an update released Friday, the US Centers for Disease Control and Prevention said there have been 2,617 MIS-C cases in the United States before March 1, and 33 children have died. That's up from early February, when 2,060 cases and 30 deaths had been reported.


MIS-C surges follow Covid-19 spikes

In the past few months, many children's hospitals, not just Chicago's, saw more cases than they had earlier in the pandemic.

"January, we just saw a huge number. We saw one a day," said Dr. Roberta DeBiasi, chief of the Division of Pediatric Diseases at Children's National Research Institute in Washington, DC. "And then in February, we were on track for that or even more, there's some days we're having two and three cases."

The surge, DeBiasi thinks, isn't due to the rise in variants, or any other phenomenon.

Typically, a surge in MIS-C follows a surge in Covid-19 cases.

The multidisciplinary MIS-C committee at her hospital noticed the trend, and as soon as they saw the spike in Covid-19 cases around the holidays, they prepared for the kids they knew would soon come four to six weeks later.

"You could set your calendar to it," DeBiasi said.
 
COVID-19 cases spike in Michigan, fueled by infections among kids

“According to state data, since February 19, average daily new COVID-19 cases among children under 10 jumped 230%, more than any other age group. The second-highest increase in infections is in the 10 to 19 age group, which saw cases rise 227%. The trends in these groups exceed that of the state as a whole.“
 
Most kids with serious inflammatory illness had mild COVID

“Most children with a serious inflammatory illness linked to the coronavirus had initial COVID-19 infections with no symptoms or only mild ones, new U.S. research shows.

The unusual post-infection condition tends to be milder in kids who were sicker with COVID-19, although more than half of affected youngsters received intensive hospital care, according to an analysis by the federal Centers for Disease Control and Prevention published Tuesday in JAMA Pediatrics.“
 
Children now playing 'huge role' in spread of COVID-19 variant, expert says

"Anywhere you look where you see this emerging, you see that kids are playing a huge role in the transmission of this," Osterholm said. "All the things that we had planned for about kids in schools with this virus are really no longer applicable. We've got to take a whole new look at this issue."

[...]

“The British Medical Journal wrote two months ago that "emerging evidence from Israel and Italy (shows) more young children are being infected with new variants of COVID-19."“
 
@weepingangel said:
More than 4,500 COVID cases confirmed among children younger than 14 over the last two weeks

Active COVID infections in Massachusetts rose to 35,075 on Wednesday, up from 34,652 on Tuesday

State health officials confirmed another 2,292 new COVID-19 cases on Tuesday. That’s based on 118,123 new molecular tests

Officials also announced another 21 COVID-related fatalities, bringing the death toll from the pandemic to 17,014.

The number of COVID patients currently hospitalized on Wednesday is 755, up from 725 the day before. Of them, 179 are in intensive care, and 105 are intubated, data shows.

The Department of Public Health added new data showing the number of infections confirmed among children younger than 15. Over the last two weeks, 1,174 cases were confirmed in children younger than 5; 1,499 infections were confirmed in children between the ages of 5 and 9; and 1,889 infections were confirmed in children between the ages of 9 and 15, according to the latest data from the Department of Public Health.

Roughly 3,031 teenagers between the ages of 15 and 19 came down with COVID between March 21 and April. And an astonishing 7,205 cases were confirmed among 20-somethings, according to DPH.

The seven-day average of positive tests is 2.46%, down slightly from 2.5% reported on Tuesday.

Since the pandemic began, officials have confirmed 611,825 total COVID-19 cases across the state.

There have been a total of 4,111,327 COVID vaccine doses administered in Massachusetts to date, and 1,571,073 residents are now fully vaccinated.
Click to expand...
 
(Not MIS-C, but related to kids:)

Kids and Long Haul Covid
 
Courtesy via @weepingangel

Rise in youth hospitalizations, COVID rates ‘very worrisome,’ says Baystate Health chief pediatrician

“SPRINGFIELD — A month ago, there was not a single case of COVID-19 to be found at Baystate Children’s Hospital. So far this month, there have five pediatric admissions with Baystate Health labs reporting an up to 9% positive rate among those under 18 years — triple the state average.

Dr. Charlotte Boney, who chairs Baystate Medical Center’s department of pediatrics and is pediatrician-in-chief, characterized the rise in admissions and the positivity rate on Friday as “very worrisome.”

“Since April 1, we have had five kids admitted with COVID-19, two of them in pediatric intensive care and one of them with post-infectious inflammatory called Multisystem Inflammatory Syndrome in Children (MIS-C),” Boney said. “It is very worrisome.”

She cited household transmission, as well as sports activities, social gatherings and “not school,” as “where these kids are getting infected.” Studies have generally shown low rates of coronavirus transmission in elementary schools that adhere to Centers for Disease Control and Prevention guidelines.

“Kids are getting infected at home, not in school,” Boney said. “They are getting it out in the community, sports, recreation, and social events. I think they are getting it from the 20-, 30-, and 40-year-olds who are not vaccinated. They are giving it to their kids who are giving it to other kids. We are very worried.”“
 
According to the doctor in this video, MIS-C can occur up to 6 months after having covid.

2 days ago:
 
As cases of MIS-C rise, mom shares 12-year-old’s experience with illness
March 4, 2021

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MIS-C: Some children's hospitals see a surge in rare Covid-19 complication - CNN
March 6, 2021

“In an update released Friday, the US Centers for Disease Control and Prevention said there have been 2,617 MIS-C cases in the United States before March 1, and 33 children have died. That's up from early February, when 2,060 cases and 30 deaths had been reported.“

—

MIS-C cases rise among children in the US | wgrz.com
March 9, 2021
 
Last edited:
Rare COVID-19 complication is putting kids in Michigan's ICUs
April 12, 2021

“Doctors are still studying the disease, but, Freij said, the syndrome might be forming due to the body’s immune response to the presence of the coronavirus.

"So the child gets infected, the immune response is supposed to help us clear this infection, but sometimes, the response is so exaggerated that this starts hurting us instead of just clearing the infected agent," he said. "So it's basically your body going into overdrive against the virus and as a result, you get this entity called MIS-C."“
 
“Earlier in the pandemic, not many children were becoming infected withthe coronavirus, and they did not appear to be major sources of virus transmission to other age groups. “That changed with B.1.1.7,” says epidemiologist Michael Osterholm, director of the Center for Infectious Disease Research and Policy. “We're now seeing substantial numbers of outbreaks in schools and in school-related activities.”

In a study conducted in the U.K., where this variant was first detected, more children were infected with B.1.1.7 than other SARS-CoV-2 variants, compared to older age groups. The same scenario is now emerging in the U.S.”

How this more contagious virus variant became dominant in the U.S.
 
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