I'm not getting a drug-fueled home invasion vibe, mainly because we've seen the animalistic behavior people on meth and other drugs are capable of on other threads here and we haven't heard anything more than two shots were heard and both parents were shot. It feels premeditated and somewhat "organized" for lack of a better word, as opposed to a druggie looking for money or kicks. JMO.
From the neighbor's statement to Banfield we've learned that they came home around 11:30. What we don't know is if the killer was already in the Closs' home by then. So IMO it's possible that Jayme's parents were tied up or otherwise disabled already. The shots heard may have been the final "kill shots" - sorry to be so graphic. IOW there may be a gap in the timeline.
CNN.com - Transcripts
Like others here I believe LE knows way more than we think. I hope that means Jayme will be located soon. MOO.