What does CMIIW mean?
Regarding friends in Italy, I think that people closed Knox off, or avoided her, rather than she closed them off. Other than the language school instructor, I don't think that anyone that knew Knox in Perugia was prepared to speak on her behalf.
1. Knox made friends with Patrick and got a job in his bar. We know what she did with that friendship.
2. She befriended the men that lived downstairs in the cottage and had a one night fling with one of them. We haven't heard anything else about him, so I think that was a short term friendship.
3. We know that Knox befriended Guede, that they had met in the plazas a couple of times and that they smoked hash or pot together in the downstairs flat. During trial, knowing that Guede participated in Meredith's murder, she stated that she was not afraid of him
4. Knox had a boyfriend in Seattle when she went to Perugia, but we know that she didn't value this relationship because she was intimate with several men shortly after arriving in Europe. In conversations with her roommates, she expressed feeling "guilt" regarding her relationships with her Seattle boyfriend and Sollecito
5. Her uncle in Germany had secured a job for her in Germany. An apartment was available for the person that filled the position. Knox showed up for the job for one or two days, then said she didn't feel well, and didn't go back. She stayed in the apartment for the time that she should have been working. I doubt she made any friends at that time.
6. Knox was introduced to Meredith's friends, but after a couple of weeks, they didn't want to spend time with her. Laura, Filomina and Meredith all attended parties on Halloween and, although Knox wanted to join Meredith and her friends, she was not invited. (p72 Massei)
7. Knox met Sollecito and immediately began staying with him at his apartment.
Generally speaking, Knox appears to have gravitated towards people that used illegal drugs, and to have intimate relationships with men that she didn't know. Healthier relationships, such as those with Laura, Filomina, Meredith and her friends, were short term and did not appear to be going anywhere.
"After inviting Knox, a Jesuit-educated student, to live with her and two other English students in their cottage,
Meredith Kercher soon began having reservations about Knox, particularly about her bringing "strange men" to the house."
http://www.theweek.co.uk/film/amanda-knox/55260/amanda-knox-film-beckinsale-joins-cast#ixzz2hzmqxFIl