Coronavirus COVID-19 - Global Health Pandemic #108

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  • #361
Dyson debuts 'Zone' headphones with odd air-purifying visor

dyson-01.jpg

I don't think I will be rushing to buy this!
 
  • #362
@jjenny, I am double vaxed with Moderna as of November, 2021 but yet have to have my booster. So would you advise a Moderna booster as well?

I'm not @jjenny but the CDC advises taking one of the MRNA vaccine boosters (either the Moderna or Pfizer booster), at least 5 months after completing your primary COVID-19 vaccination series.
COVID-19 Booster Shot
 
  • #363
I'm not @jjenny but the CDC advises taking one of the MRNA vaccine boosters (either the Moderna or Pfizer booster), at least 5 months after completing your primary COVID-19 vaccination series.
COVID-19 Booster Shot

Thanks. A question I have, however, is whether to have a Moderna or Pfizer booster. As they are both MRNA, would it make any difference? I really like Moderna as I haven't heard anything negative about it. I am flying to Dublin in July, so I thought I would have my booster in May.

Any advice is welcome.
 
  • #364
Thanks. A question I have, however, is whether to have a Moderna or Pfizer booster. As they are both MRNA, would it make any difference? I really like Moderna as I haven't heard anything negative about it. I am flying to Dublin in July, so I thought I would have my booster in May.

Any advice is welcome.

I think the only difference is that if you have a Pfizer booster, you might get some benefit from it being slightly different from Moderna. But if you want to have a Moderna booster, that's fine!

Here's what I wrote earlier in this thread:
I've had the Pfizer shots and booster, but I'm considering getting Moderna for my fourth shot. Dr. Eric Feigl-Ding suggests it would probably be a good idea to switch up boosters. He cites this paper in Science Translational Medicine:
mRNA-1273 and BNT162b2 COVID-19 vaccines elicit antibodies with differences in Fc-mediated effector functions
https://www.science.org/doi/10.1126/scitranslmed.abm2311

Excerpt from abstract:
"...real-world vaccine efficacy has begun to show differences across the two approved mRNA platforms, BNT162b2 [Pfizer] and mRNA-1273 [Moderna]; these findings suggest that subtle variation in immune responses induced by the BNT162b2 and mRNA-1273 vaccines may confer differential protection."
 
  • #365
  • #366
Not sure if someone has already posted about a new omicron subvariant that has emerged in the UK, called XE which is a combination of omicron BA.1 and BA.2. Not a variant of concern at this time, but WHO is watching it.

https://www.nbc4i.com/news/u-s-world/new-mutant-omicron-variant-xe-could-be-most-transmissible-yet-who-says/?nxs_link=article-image_3_title_1&email=1f691e70cf5d530b3f7620c85607caee3dbb0b52&utm_source=Sailthru&utm_medium=email&utm_campaign=Curated Daily News 2022-04-02&utm_term=Daily News

Just days after the BA.2 strain of coronavirus achieved world dominance, international health officials are already turning their attention to a new, mutant variant believed to be even more transmissible – XE.

XE is a combination of the first form of omicron to spread across the globe, BA.1, and so-called “stealth omicron,” the subvariant BA.2, that is now dominant.

The highly transmissible XE strain was first detected in the United Kingdom on January 19, according to the WHO document, and there have been more than 600 documented cases in the UK since.

Preliminary findings suggest that XE may be about 10% more transmissible than BA.2, which is considered 50-60% more transmissible than its omicron predecessor, according to Dr. Anthony Fauci, the nation’s top infectious disease expert.

How deadly XE turns out to be is still a question mark when it comes to XE as health experts continue to monitor the subvariant’s spread.

“The transmissibility and the severity of this new recombinant variant is still being investigated, so we will closely monitor the latest situation,” said Chuang Shuk-kwan, head of the Communicable Disease Branch at Hong Kong’s Center for Health Protection (CHP).
 
  • #367
  • #368
I think the only difference is that if you have a Pfizer booster, you might get some benefit from it being slightly different from Moderna. But if you want to have a Moderna booster, that's fine!

Here's what I wrote earlier in this thread:
The abstract says Moderna elicited higher concentrations of those cells and antibodies. I had Moderna for all of mine 4 shots. Data pretty much shows that Moderna is the best vaccine of the three used in the US in terms of preventing deaths. When I was exposed to covid by an infected relative (that was after two primary Modernas and one Moderna booster) apparently I never even got infected. My relative who was immuno compromised was infected despite being vaxxed and boosted (with Pfizer for all three). Because relative was on immuno suppressants maybe Moderna would have not worked for the relative either, but there is no way to know.
 
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  • #369
@jjenny, I am double vaxed with Moderna as of November, 2021 but yet have to have my booster. So would you advise a Moderna booster as well?
First booster is recommended after five months. All of mine were Moderna's. I think Moderna is a bit stronger than Pfizer.
 
  • #370
John Campbell has a new video discussing the new XE strain, which is a recombinant variant of Omicron BA.1 and BA.2. He says that bottom line, he isn't worried about it, but it's interesting.

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  • #371
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  • #373
Let's see if I can post links...

Human genetic variants identified that affect COVID susceptibility and severity

Basically, if you do not have one of these 13 loci, you are going to be just fine.

This study reported in the journal, Nature, is certainly interesting and I look forward to reading further research on the link between human genetics and severity of Covid. However, the study does not say that those without a known genetic link will be just fine. That is most certainly not true.

There are many other factors that the study alludes to which affect outcomes, including age, access to health care, underlying conditions, and other socio-demographic factors which we all know about and have seen during these past two years. In addition, not all the genetic links have been found. The study is far from over.
 
  • #374
Let's see if I can post links...

Human genetic variants identified that affect COVID susceptibility and severity

Basically, if you do not have one of these 13 loci, you are going to be just fine.

I think that there will be very few people who know if they personally have a variant in one or more of these 13 loci.

We are rarely sent for genetic testing, unless there is a specific reason. And if we are sent for genetic testing, the dr is looking for a variant in a specific gene - due to other indicators that all may not be well in a particular area of our health.

imo
 
  • #375
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I don't think I will be rushing to buy this!
:D
 
  • #376
Let's see if I can post links...

Human genetic variants identified that affect COVID susceptibility and severity

Basically, if you do not have one of these 13 loci, you are going to be just fine.
That's an interesting paper, but not particularly useful in any real way. Covid is a population-level epidemiological problem. The conclusion that some individuals are more susceptible to severe disease than others doesn't stop the spread of the disease in the population as a whole. Which is the actual problem.

IMO
 
  • #377
  • #378
Let's see if I can post links...

Human genetic variants identified that affect COVID susceptibility and severity

Basically, if you do not have one of these 13 loci, you are going to be just fine.

Ummm…so how do I know I’m “going to be just fine” if I don’t know if I have these genetic variants mentioned in the article? This is of no practical value in the real world of this pandemic that has killed millions and caused long term effects in countless others. Minimizing the severity of Covid-19 is not allowed here.
 
  • #379
  • #380
Covid boosters: FDA advisers to meet to discuss what shots we'll need next (nbcnews.com)

The panel meets Wednesday as some experts question whether getting additional doses every few months is a practical public health strategy.

Food and Drug Administration advisers will meet Wednesday to hash out what the future of Covid-19 boosters looks like in the United States.

It's a question that looms large: Just a week ago, the FDA and the Centers for Disease Control and Prevention signed off on a second booster dose for people ages 50 and up, four months after their first booster.

But fewer than half of eligible adults have even received that first booster shot, and some health experts question whether getting additional doses of the vaccines every few months to protect against mild illness is a practical public health strategy...
 
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