Could nearly half of those with Covid-19 have no idea they are infected?
As studies confirm many infected people show no symptoms, contact tracing and face masks assume even greater importance
When Noopur Raje’s husband fell critically ill with Covid-19 in mid-March, she did not suspect that she too was infected with the virus.
Raje, an oncologist at Massachusetts General Hospital in Boston, had been caring for her sick husband for a week before driving him to an emergency centre with a persistently high fever. But after she herself had a diagnostic PCR test – which looks for traces of the Sars-CoV-2 virus DNA in saliva – she was astounded to find that the result was positive.
“My husband ended up very sick,” she says. “He was in intensive care for a day, and in hospital for 10 days. But while I was also infected, I had no symptoms at all. I have no idea why we responded so differently.”
It took two months for Raje’s husband to recover. Repeated tests, done every five days, showed that Raje remained infected for the same length of time, all while remaining completely asymptomatic. In some ways it is unsurprising that the virus persisted in her body for so long, given that it appears her body did not even mount a detectable immune response against the infection.
When they both took an antibody test earlier this month, Raje’s husband showed a high level of antibodies to the virus, while Raje appeared to have no response at all, something she found hard to comprehend.
“It’s mind-blowing,” she says. “Some people are able to be colonised with the virus and not be symptomatic, while others end up with pretty severe illness. I think it’s something to do with differences in immune regulation, but we still haven’t figured out exactly how this is happening.”
Epidemiological studies are now revealing that the number of individuals who carry and can pass on the infection, yet remain completely asymptomatic, is larger than originally thought. Scientists believe these people have contributed to the spread of the virus in care homes, and they are central in the debate regarding face mask policies, as health officials attempt to avoid new waves of infections while societies reopen.
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From the microbe’s perspective, this makes perfect evolutionary sense. “For any virus or bacteria, making people infectious but not ill is an excellent way to spread and persist in populations,” says Rein Houben, an infectious diseases researcher at the London School of Hygiene and Tropical medicine.
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“Almost all evidence seems to point to a proportion of asymptomatic infections of around 40%, with a wide range,” says Houben. “The proportion is also highly variable with age. Nearly all infected children seem to remain asymptomatic, whereas the reverse seems to hold for the elderly.”
Houben points out that, because most asymptomatic people have no idea they are infected, they are unlikely to be self-isolating, and studies have shown this has contributed to the rampant spread of the virus in facilities such as
homeless shelters and
care homes. He says this means there is a need for regular diagnostic testing of almost all people in such closed environments, including prisons and psychiatric facilities.
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For Raje, understanding why asymptomatic patients like her respond the way they do to the virus, will have some critical implications for all of us over the coming months, for example in determining whether vaccines turn out to be effective.
“The big question I have after my experience, is whether a vaccine will really work in all people,” she says. “The vaccination approach is to create an immune response, which then protects you. But if asymptomatic people are not producing a normal antibody response to the virus, what does that mean? Because it’s these people who are the vectors and the carriers of this virus, I think we can’t get away from social distancing until we have some of these answers out there.”
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Could nearly half of those with Covid-19 have no idea they are infected?