- Joined
- Jun 27, 2019
- Messages
- 15,972
- Reaction score
- 201,571
The main reason that older people die of CoVid, it seems, is that our immune systems start losing strength after age 60-65 (on average, obviously, some people it's older, some it's younger).
In order to combat CoVid, we need to have available T cells in our bone marrow (not just antibodies in our blood). The T cells are the memory system of immunity.
Each time we get a disease that creates antibodies, some T cells devote themselves to remembering how to produce those antibodies. So, we know that people who have had a different coronavirus in the past are very unlikely to have a severe course of CoVid. It's not easy to study this though and there are no cheap or even widely available tests for this.
As we age, the number of available T cells drops until there are no more left (average age of that is probably 85). Not only can the body not fight off new infections easily, it can't store memory of a new infection.
So, whether inside a nursing home or not, an elderly person has a much higher likelihood of dying from CoVid (or having a longterm set of symptoms or possibly even recurrences).
The number of total infections we've had in our lives (including, as I understand it, immune responses to vaccines) "uses up" the T cells - but if a new virus is closely related to one we've experienced, we do get a better response.
CoVid is a slow-mutating virus (fortunately) as compared to many rhinoviruses and to influenzas. Some people may have already had a prior version and therefore, despite being elderly, will be able to formulate a better immune response..
There are other effects from aging on immunity, but T cell immunity is key in fighting off CV. Our bodies need to be able to throw early responses at it and not move toward bradykine or cytokine storms (where the body attacks itself, basically, in attempt to kill the invader)
In order to combat CoVid, we need to have available T cells in our bone marrow (not just antibodies in our blood). The T cells are the memory system of immunity.
Each time we get a disease that creates antibodies, some T cells devote themselves to remembering how to produce those antibodies. So, we know that people who have had a different coronavirus in the past are very unlikely to have a severe course of CoVid. It's not easy to study this though and there are no cheap or even widely available tests for this.
As we age, the number of available T cells drops until there are no more left (average age of that is probably 85). Not only can the body not fight off new infections easily, it can't store memory of a new infection.
So, whether inside a nursing home or not, an elderly person has a much higher likelihood of dying from CoVid (or having a longterm set of symptoms or possibly even recurrences).
The number of total infections we've had in our lives (including, as I understand it, immune responses to vaccines) "uses up" the T cells - but if a new virus is closely related to one we've experienced, we do get a better response.
CoVid is a slow-mutating virus (fortunately) as compared to many rhinoviruses and to influenzas. Some people may have already had a prior version and therefore, despite being elderly, will be able to formulate a better immune response..
There are other effects from aging on immunity, but T cell immunity is key in fighting off CV. Our bodies need to be able to throw early responses at it and not move toward bradykine or cytokine storms (where the body attacks itself, basically, in attempt to kill the invader)