I'm a fence-sitter in this case, but I do think the McCanns sedated those children. Just picture a building 100 yards from where you are at the moment and imagine there are three young toddlers, for whom you are responsible, inside there asleep. How could you not imagine them waking up and sticking their fingers in electric sockets, drinking poison, climbing on high cabinets, drowning in the toilets, etc, etc, unless you had drugged them? Or tied them up, I guess.
Seriously criminally negligent no matter what way you look at it.