I have a friend who refers to Breezewood as "America's Rest Stop". When you have US 30, I-76 (Turnpike), and I-70 coming together, it leaves far too many possibilities. Keep in mind I-76 has an interchange with I-80 just 23 miles into Ohio near Lordstown. Both 70 and 80 cross the country and 80 itself connects with I-90 near Cleveland. You're also just a few hours from I-95 and I-77.
Since Breezewood usually has more travelers drive through than it has population, pretty much any city is fair game. How close the home city is depends on how much of a roadtripper the killer was. Breezewood is very well-known around the area for being a stop here, but it's people from the general area (PA, MD, WV, parts of OH in particular) who are more aware of it since they have used it to go to/from Baltimore, Philly, Pittsburgh, Cleveland, etc.