Marie Scott left home in the middle of the day, caught a train to the city centre and disappeared. She was captured on CCTV in a number of places which confirmed her route.
She had been suffering from depression since the death of her mother and had made a few suicide attempts. It was her 58th birthday on Boxing Day. It is believed she may have travelled through Devon to Cornwall, but has not been seen getting on any other trains.

http://www.itv.com/news/granada/2017-12-22/concern-for-missing-manchester-mum/
http://www.dailymail.co.uk/news/article-5217447/Missing-Manchester-womans-son-appeal-her.html
http://www.missingpeople.org.uk/help-us-find/marie-scott-17-006931
She had been suffering from depression since the death of her mother and had made a few suicide attempts. It was her 58th birthday on Boxing Day. It is believed she may have travelled through Devon to Cornwall, but has not been seen getting on any other trains.

http://www.itv.com/news/granada/2017-12-22/concern-for-missing-manchester-mum/
http://www.dailymail.co.uk/news/article-5217447/Missing-Manchester-womans-son-appeal-her.html
http://www.missingpeople.org.uk/help-us-find/marie-scott-17-006931