I am an extremely tolerant person and very accepting of people's differences. It just concerns me when we can become so comfortable with mental disorders. There are people who think they are aliens.....are we discriminating against them if we don't accept their feelings?
Well I think of it this way: whatever will help the person get better and live more functionally is probably the better option.
if Bruce Jenner feels happier and like a more fulfilled, functional person as Caitlyn, it isn't really relevant if I accept his feelings or not. It's Jenner's life, Jenner's feelings, not mine. Bruce/Caitlyn is the best judge of that, and it's no skin off my nose really. Besides, there's precious little that anybody can do to help transgender people feel more like their biological gender again, it's a relatively stable state, and the risk of suicide is very high. So if the choice is that he/she is unhappy feeling trapped in his/her body that feels wrong all the time, or that the transgender person gets to choose the gender that suits him or her the best although I'm slightly uncomfortable occasionally, not knowing what to think of transgenderism, (whenever I happen to think about it which is not that often), it seems quite clear to me which matters the most.
People with delusions and hallucinations are frequently quite scared, anxious and unable to function, living with the beliefs, and it's not a steady state, sometimes it passes without intervention or there might be medications or treatments that could help them. It's easier to be cured of psychosis than from being transgender, so worth a try. But sometimes if the drugs don't work and the delusional person is in a safe environment and not in any danger from the delusions, and gets very upset and agitated when anyone suggests that they're not an alien, I might just go with it and let them think whatever they will think anyway and just try to make sure the person doesn't end up hurting themselves.
Slurs and contempt won't help either the transgender person or the psychotic one.