Given the frequency of contact between humans and domestic dogs, canine Ebola infection must be considered as a potential risk factor for human infection and virus spread. Human infection could occur through licking, biting, or grooming. Asymptomatically infected dogs could be a potential source of human Ebola outbreaks and of virus spread during human outbreaks, which could explain some epidemiologically unrelated human cases. Dogs might also be a source of human Ebola outbreaks, such as the 1976 Yambuku outbreaks in Democratic Republic of Congo (19), the 1995 Kikwit outbreak, some outbreaks that occurred in 1996 and 2004 in Gabon and Republic of Congo (5), and the 1976 (6), 1979 (20), and 2004 (21) outbreaks in Sudan, the sources of which are still unknown. Together, these findings strongly suggest that dogs should be taken into consideration during the management of human Ebola outbreaks.