12:26pm: Mr Byrne said the Baden-Clays' relationship took a turn for the worst during their trip to South America.
Mrs Baden-Clay was prescribed the controversial anti-malaria drug Lariam for the duration of the trip which has been linked with depression and anxiety.
"That trip turned into an emotional roller coaster ... the ideal marriage changed," Mr Byrne said.
"Allison for the first time ... started to have severe mood swings during that period. There were days when she wouldn't leave her room. She would be listless, restless, she couldn't function at the normal bouncy Allison self. The next day she would be fine, back to her normal self, and they would get on.
"They travelled to Switzerland as part of their involvement again as part of the scouting movement."
Mr Byrne explained there was a high-risk of avalanche where the Baden-Clays' were staying in the Swiss Alps.
"And he'll tell again Allison reacted to that. She felt literally like the sky was falling ...and when that became a real possibility she lapses, as he describes, into a deep depression," Mr Byrne said.
"That affected their relationship, their good times together, and indeed their intimate relationship."
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