magikarpmagikarp
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I believe that the "almost always" fatal claim likely comes from the 1989 Lee and Tanswell paper:
This was also the paper that was mentioned by Dr Jayaram. I suspect the core problem on both the prosecution and defence side is that this is not a condition where there's an awful lot of empirical information out there, which would be why they're both having to reach back to this one very old case series, as it might be the only relevant paper out there.
Agreed. This paper is on Pulmonary Venous Embolism in premature infants. It does describe the skin changes seen with embolism and it describes the effects of embolism on the body. PVE is specifically an embolism due to damage to the lungs from a ventilator. This happened in the era of neonatology that existed before surfactant replacement therapy, steroids before delivery, and modern "permissive" ventilation strategies that are intended to protect the lungs from damage. Basically ventilator pressures are so high than lung tissue ruptures. Usually that would have resulted in pneumothorax or pulmonary interstitial emphysema, but in some cases it allowed air to enter circulation, causing PVE. You would not see PVE in 2015 except in exceedingly rare circumstances with a very critically ill patient. With an injected air embolism, there is only so much air to go around. It's what was injected in, and no more. With a PVE there's a chance for ongoing air entry, to the point that one of the diagnostic characteristics is frothy blood withdrawn from the umbilical line. The paper's authors recommend switching to 100% FiO2 if PVE is suspected, because having the bubbles be oxygen instead of air (which is mostly nitrogen) may mitigate some of the damage. They also point out that if the patient is on pressures high enough to cause PVE, they are likely already on 100% FiO2. Because this condition was a rare complication of the treatment strategies available at the time, there were eventually enough cases to be written up collectively. On the other hand, cases of air embolism from intravenous lines in infants are most likely going to be the result of medical error, and are typically reported as single cases.