Its seems like either she left everything behind to start a new life where no one could track her down, or she killed herself, or her husband killed her. To start a new life taking nothing, not her car or money or personal things, she'd need someone's help. I suspect the "talk" far into the night was more like an argument. Did it get out of control? Did he do something to her? Did she rush out of there mad and find somewhere to go and a way to get there? It's said that she cares very much for her son and grandchild, would she just leave them behind to start a new life? I tend to think that the husband had something to do with her disappearance. Maybe the police are saying he's not a suspect so he will be comfortable enough to let something slip that would lead to finding out what happened to her. I think its unlikely that someone came and kidnapped her during the short time that her husband was sleeping. And, according to him, she was dressed in clothes and not night clothes when he saw her last. Her husband might have felt threatened by her losing weight and starting a new life that she was in control of, not him.