kittythehare
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Anatoxin Ahttps://www.sacbee.com/article254080593.html
Sept 8, 2021
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Few clues have been shared by investigators working to determine how a family and their dog died a little over three weeks ago while hiking in Sierra National Forest, in a remote section of Mariposa County southwest of Yosemite National Park.
Known harmful algae blooms in the south fork of the Merced River, near where the family was mysteriously found dead along the Savage-Lundy Trail in Devil’s Gulch, are among the hazards being considered.
[..]
The results of toxicology tests for the Mariposa family have not been shared.
In response to a question during Thursday’s sheriff update, about whether toxicology results were back yet, Briese said, “Some are, yes. But we still do not have an exact cause of death yet.”
(2009)
No documented case of human anatoxin-a poisoning has been found in the literature, whereas numerous cases of animal poisoning have been reported. In France, for example, the death of several dogs has been attributed to the consumption of benthic anatoxin-a-producing cyanobacteria (Gugger et al., 2005).
Anatoxin - an overview | ScienceDirect Topics.
Anatoxin-a is a potent nerve toxin that acts postsynaptically. Synapses are a physical gap between nerves, and nerve and muscles, which must be traversed by any nerve impulse. This is achieved by the neurochemical acetylcholine moving across the synaptic junction. On the receiving side of a synapse, one finds acetylcholine receptors in the cell membrane that open when they bind acetylcholine to allow the entry of many ions into the nerve or muscle. Increased intracellular cations depolarize the receiving cell triggering a cascade of events that continue the action potential. Anatoxin-a is a powerful agonist of acetylcholine receptors being many times better than acetylcholine itself in stimulating the receptor to open. Anatoxin-a therefore outcompetes and displaces acetylcholine overstimulating the receptor, impairing its function and incapacitating nerve and muscle.
Acetylcholine receptors can be prepared from a variety of excitable tissues from animals. An example is the electric organ of electric eels, a very dense concentration of excitable tissue and a source of many neuronal receptors. A number of other chemicals competitively bind with anatoxin-a for the acetylcholine receptor (e.g., nicotine, acetylcholine itself, α-bungarotoxin) and have been radiolabeled and used in receptor binding assays for anatoxin-a.
Further reading
Potential developmental toxicity of anatoxin-a, a cyanobacterial toxin - PubMed
Anatoxin-a
https://www.epa.gov/sites/default/files/2017-06/documents/anatoxin-a-report-2015.pdf
https://www.who.int/water_sanitatio...ls/anatoxin-a-gdwq-bd-for-review-20191122.pdf