Coronavirus COVID-19 - Global Health Pandemic #80

[Sarahlou]

IMO Biden isn't blaming anyone. Simply encouraging everyone to use the only tools we have at this time.

Exactly. He's just speaking common sense.

 

[Medstudies]

I already edited my post after reading that they have 60 enrolled in the study, starting in July and have to be aged 18-45. Would be interesting to follow the study though.

Hmmm. This is the inclusion/exclusion criteria for the study I linked:
(Ita that this will be interesting to watch)

Ages Eligible for Study: 12 Years and older (Child, Adult, Older Adult)
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Criteria
Key Inclusion Criteria:

• Willing and able to provide written informed consent, or with a legal representative who can provide informed consent (individuals ≥ 18 years of age) or assent (individuals ≥ 12 and < 18 years of age) prior to performing study procedures. For individuals ≥ 12 and < 18 years of age, a parent or legal guardian must be willing and able to provide written informed consent prior to performing study procedures
• Either:
  • Age ≥ 18 years (at all sites) or aged ≥ 12 and < 18 years of age weighing ≥ 40 kg (where permitted according to local law and approved nationally and by the relevant institutional review board (IRB) or independent ethics committee (IEC) with at least 1 pre-existing risk factor for progression to hospitalization (chronic lung disease, hypertension, cardiovascular or cerebrovascular disease, diabetes, obesity (body mass index ≥ 30), immunocompromised, chronic mild or moderate kidney disease, chronic liver disease, current cancer, or sickle cell disease)
  • OR aged ≥ 60 years
• SARS-CoV-2 infection confirmed by polymerase chain reaction (PCR) ≤ 4 days prior to screening
• Presence of ≥ 1 symptom(s) consistent with COVID-19 for ≤ 7 days prior to randomization
• Oxygen saturation (SpO2) > 94% on room air
• Not currently requiring hospitalization

Key Exclusion Criteria:

• Participation in any other clinical trial of an experimental treatment and prevention for COVID-19
• Prior hospitalization for COVID-19
• Treatment with other agents with actual or possible direct antiviral activity against SARS-CoV-2
• Use of hydroxychloroquine or chloroquine ≤ 7 days prior to screening
• Requiring oxygen supplementation

Again - the link for those interested: Study to Evaluate the Efficacy and Safety of Remdesivir (GS-5734™) Treatment of Coronavirus Disease 2019 (COVID-19) in an Outpatient Setting - Full Text View - ClinicalTrials.gov


And an excerpt:
Official Title: A Phase 3 Randomized, Double-Blind Placebo-Controlled Trial to Evaluate the Efficacy and Safety of Remdesivir (GS-5734™) Treatment of COVID-19 in an Outpatient Setting
Actual Study Start Date : September 18, 2020
Estimated Primary Completion Date : December 2020
Estimated Study Completion Date : January 2021

 

[Bravo]

Exactly. He's just speaking common sense.

Yep just following the Science

 

[tresir2012]

Memorandum from Vice President Pence’s Physician | The White House



MEMORANDUM FOR: MARC SHORT, ASSISTANT TO THE PRESIDENT AND CHIEF OF STAFF TO THE VICE PRESIDENT

FROM: JESSE T. SCHONAU, MD, FAAFP, WHITE HOUSE PHYSICIAN, LIEUTENANT COMMANDER, U.S. NAVY

SUBJECT: Vice President Mike Pence

I release the following information with the permission of Vice President Mike Pence.

Earlier this morning under my care, Vice President Mike Pence tested negative for COVID-19.

Under the guidelines of the Centers for Disease Control (CDC), the Vice President is not considered a close contact with any individuals who have tested positive for COVID, including President Donald J. Trump. Vice President Mike Pence does not need to quarantine.

Vice President Mike Pence remains in good health and is free to go about his normal activities.

https://www.whitehouse.gov/wp-content/uploads/2020/10/MemoFromPresidentsPhysician.png

 

[nhmemorymaker]

IMO, when it gets to the stage that 'the news' consists of different news media outlets covering each other's coverage, it's time to turn to the sports section or something equally grounded in reality.

In this case, I would agree totally.

 

[Medstudies]

Hmmm. This is the inclusion/exclusion criteria for the study I linked:
(Ita that this will be interesting to watch)

Ages Eligible for Study: 12 Years and older (Child, Adult, Older Adult)
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Criteria
Key Inclusion Criteria:

• Willing and able to provide written informed consent, or with a legal representative who can provide informed consent (individuals ≥ 18 years of age) or assent (individuals ≥ 12 and < 18 years of age) prior to performing study procedures. For individuals ≥ 12 and < 18 years of age, a parent or legal guardian must be willing and able to provide written informed consent prior to performing study procedures
• Either:
  • Age ≥ 18 years (at all sites) or aged ≥ 12 and < 18 years of age weighing ≥ 40 kg (where permitted according to local law and approved nationally and by the relevant institutional review board (IRB) or independent ethics committee (IEC) with at least 1 pre-existing risk factor for progression to hospitalization (chronic lung disease, hypertension, cardiovascular or cerebrovascular disease, diabetes, obesity (body mass index ≥ 30), immunocompromised, chronic mild or moderate kidney disease, chronic liver disease, current cancer, or sickle cell disease)
  • OR aged ≥ 60 years
• SARS-CoV-2 infection confirmed by polymerase chain reaction (PCR) ≤ 4 days prior to screening
• Presence of ≥ 1 symptom(s) consistent with COVID-19 for ≤ 7 days prior to randomization
• Oxygen saturation (SpO2) > 94% on room air
• Not currently requiring hospitalization

Key Exclusion Criteria:

• Participation in any other clinical trial of an experimental treatment and prevention for COVID-19
• Prior hospitalization for COVID-19
• Treatment with other agents with actual or possible direct antiviral activity against SARS-CoV-2
• Use of hydroxychloroquine or chloroquine ≤ 7 days prior to screening
• Requiring oxygen supplementation

Again - the link for those interested: Study to Evaluate the Efficacy and Safety of Remdesivir (GS-5734™) Treatment of Coronavirus Disease 2019 (COVID-19) in an Outpatient Setting - Full Text View - ClinicalTrials.gov


And an excerpt:
Official Title: A Phase 3 Randomized, Double-Blind Placebo-Controlled Trial to Evaluate the Efficacy and Safety of Remdesivir (GS-5734™) Treatment of COVID-19 in an Outpatient Setting
Actual Study Start Date : September 18, 2020
Estimated Primary Completion Date : December 2020
Estimated Study Completion Date : January 2021

and tagging off my post...

Could President Trump receive experimental Covid-19 treatment? - STAT


Scott Gottlieb, who served as the commissioner of the FDA earlier in Trump’s term, said he thinks it would be “reasonable to consider” giving him remdesivir.

“If the reports are true that the president is symptomatic, I think it would be reasonable to consider giving him remdesivir, given that we have good information about that drug’s profile, and this is the president of the United States, so we want to lean forward on getting him the best possible care,” Gottlieb said.

Gottlieb acknowledged that remdesivir, technically, is cleared only for patients who are in the hospital, so this would be “off-label,” but he said that its safety profile is well-understood and it’s “reasonable” to believe that it could help patients earlier in their illness.

 

[nhmemorymaker]

“@Joe Biden
I’m happy to report that Jill and I have tested negative for COVID. Thank you to everyone for your messages of concern. I hope this serves as a reminder: wear a mask, keep social distance, and wash your hands.”


Glad to see Biden and his wife have tested negative for coronavirus for now at least, however is it not quite irresponsible for him to imply a bit of victim blaming here? he aught to know himself there is NO PROOF WHATSOEVER that masks protect you against coronavirus, even those who take all the necessary precautions can still catch covid-19. I do hope he isn’t suggesting the 32million people worldwide that have caught coronavirus upto now haven’t been “careful enough”

just saying.

Well, if i could encourage you of anything, it would be to wear a mask, keep a social distance, and wash your hands.

 

[margarita25]

I think doctors will be giving them remdesivir right now ... if that is a safe thing to do while asymptomatic.

This probably will turn out to not be a huge concern. I am sometimes amazed that the Queen just lives on and on - but she has the best doctors taking care of her every need, so the world does not even hear of any medical issues (of which there must be a few, at her age, I would think).

IMO

If I understand correctly, remdesivir is used in treatment of severe infection/serious illness. I just saw an update with Kayleigh M, his Press Secretary, and she said so far he is having mild symptoms. But maybe he will take it anyway, I don’t know, but from what I recall it is not recommended for mild disease, and can be dangerous. I specifically remember Dr. Mike talking about this. Jmo.

 

[nhmemorymaker]

Sure, but you can wear a mask, wash your hands, keep a distance, and still catch covid 19.

Yes, you can wear a seat belt, stay sober, stay awake, and still die in a car crash.
Is that kindof your point?

 

[Bravo]

Well, if i could encourage you of anything, it would be to wear a mask, keep a social distance, and wash your hands.

Yep. I can speak for myself from back in March. I was exposed to 5 at work. I followed the Science very early in and was mocked a bit at work. I didn't get covid. Seems it worked out well for me.

 

[margarita25]

BBM:

@Tom_Winter

NBC News: President Trump is being treated with an 8 gram dose/infusion of Regeneron's polyclonal antibody cocktail, his doctor says
Also zinc,vitamin D, aspirin and other things.

Interesting, marking to research this cocktail. (Eta: I recall much discussion about monoclonal antibodies via Dr. Swaminathan, but not polyclonal.)

 

[Bravo]

Even tho my City is down to 3 active cases we have not changed anything. Things can change rapidly. Especially with winter coming. We are doing our darnedest to get thru this. We have a lot of living to do yet.

 

[JerseyGirl]

BBM:


Interesting, marking to research this cocktail.

Regeneron's antibody cocktail for coronavirus: Early data shows promising results

... said that, along with Regeneron's earlier work published in a peer-reviewed journal in August, the additional key takeaway is that the "cocktail" approach is effective.

A cocktail antibody therapy uses two or more lab-engineered antibodies. Regeneron's cocktail includes a monoclonal antibody that targets the spike protein the virus uses to drill into healthy cells, and another antibody that targets a different part of the novel coronavirus. With two, the hope is is to trap and shut down viral replication.

 

[IceIce9]

Many will test negative today but it doesn't mean they will tomorrow. It's imperative they isolate IMO

We had two patients of our clinic who were exposed to COVID. The husband was very, very, sick with all the classic COVID symptoms. Wife had no symptoms whatsoever.

Husband tested negative in 2 COVID tests. Wife tested positive in 2 tests.

Our clinic doctor was so sure that the husband had COVID that he sent him for a chest x-ray. The x-ray interpretation showed signs of COVID.

 

[tresir2012]

@Tom_Winter

NBC News: President Trump is being treated with an 8 gram dose/infusion of Regeneron's polyclonal antibody cocktail, his doctor says
Also zinc,vitamin D, aspirin and other things.

I just looked on the WH website but couldn't find that memo. It is also in this NBC updating log link below too though.

Live updates: Trump experiencing 'mild symptoms' of Covid-19

The BBC link below has a video about monyclonal antibody trials

Antibody treatment to be given to Covid patients

and here is a link to Regeneron's study details.

Regeneron's REGN-COV2 Antibody Cocktail Reduced Viral Levels and Improved Symptoms in Non-Hospitalized COVID-19 Patients | Regeneron Pharmaceuticals Inc.

 

[gitana1]

Also, remdesivir is not without its risks. It is also in short supply (many local hospitals have none of it - and that’s true of the other newer anti-virals and possible therapeutics that get reported on). Here in SoCal, you really need to check out your hospitals (even the USC and UCLA affiliated ones do not all have adequate supplies of the newer anti-virals should we see a big uptick).

However, if I had CoVid, I would definitely want to go to a hospital with a UCLA hospitalist (a doctor who specializes in getting proper resources to the patient from throughout the UCLA system - the nearest one to me is about 40 minutes away).

I’ve got Kaiser. I don’t know that they’d do much.

 

[casesensitive]

You can trace back the conversation by using the 'up arrow' on each in the series of posts, no need for anyone to retype it.

Wow, thanks Satchie! I've been a member for over 12 years and never noticed that little arrow.

 

[gitana1]

Gilead CEO: We're studying new ways to treat coronavirus with remdesivir outside of the hospital


“O'Day said Monday that Gilead this month began trials to look at using IV remdesivir in outpatient settings, which may make it possible to "keep people out of the hospital in high-risk cases."

He noted the California-based company also has been testing the drug, which had previously been studied as a potential Ebola treatment, to be used in inhaled form for Covid-19 patients. Those trials began in July.

"If one could do it without an IV, right to the site of where you get this replication of the virus in the lungs, we're also hopeful that you might be able to treat outside the hospital and prevent patients from ever going to the hospital," said O'Day, who became Gilead CEO in March 2019.”

I have no idea if this is something that is being offered to POTUS and vital associates, but considering how NBA and celebrities were able to get tests when the general public couldn’t get their hands on them? Nothing would surprise me.

Of course. Rich people get whatever they can. They have private doctors willing to do things the rest of us can’t get with our insurance coverage and medical group protocols. Their doctors are willing to go outside the box.

I’m not discussing the fairness of that. My concern is that the ability of the elite to recover fast and/or not experience the level of illness that they could have had they not had that level of care, should not, but will be taken as a sign that COVID is not that dangerous.

That’s been a problem and will be an even greater problem now, IMO.

 

[sds71]

@abbydphillip
·
WH pool reports the President Trump is going to Walter Reed Medical Center shortly.
Will fly and spend a few days there.

 

[SeattleStew]

Trump going to Walter Reed per NBC news.