Ran out of time on above post, continued below:
Qmfr:
BBM
COVID-19 and MIS-C: Two Diseases, One Virus in Kids
— Both clinical profiles and even outcomes varied, researcher says
Nov. 17, 2020
“Pediatric patients with acute COVID-19 and those with multi-system inflammatory syndrome in children (MIS-C) had evidence of acute liver injury, but each group had different clinical features, a researcher said.
MIS-C patients were younger, had more ICU admissions, and higher levels of inflammatory markers, while COVID-19 patients with acute liver injury were more likely to have higher BMI, reported Amanda Cantor, MD, of Columbia University in New York City.
In fact,
BMI was significantly associated with degree of liver injury among kids with COVID-19, but not MIS-C, she said in a presentation at theAmerican Association for the Study of Liver Diseases virtual meeting.
Cantor described how there were "two distinct clinical phenotypes caused by the same virus."
She and her colleagues added that MIS-C "changed the perception of the severity of this infection in children," as pediatric manifestations of COVID-19 in children were thought to be mild.“
—
Now, keep in mind,
this is just one hospital, and as seen in the above quoted post, this is not the only hospital to say they are seeing more and more patients:
“While the CDC classifies MIS-C as rare, the doctors treating Vivian told her family they're seeing a kid a week show up with symptoms.“
MIS-C in Atlanta child who had COVID-19 | wtsp.com
—
News 8: What’s it like treating these patients?
McGee: I’d rather not have to do it. These are children that can get very, very sick and as I’ve said before some of these kids can die. This virus is real. This virus is dangerous. It doesn’t matter whether you’re a child or an adult. So, we all have to be careful to make sure we don’t get it because your child could be the one that suffers from a major consequence.“
—
Re: Here is another reason why I think it’s possible we are not seeing the full spectrum here:
“Nelson Delacruz, an epidemiologist for the state, confirmed the hospital’s cases had been reported.
But while public health investigators counted them toward Virginia’s COVID-19 cases, they did not for MIS-C.
That’s because the department did not consider them to meet the U.S. Centers for Disease Control and Prevention’s narrow definition for the syndrome. Delacruz could not elaborate on how the cases differed.“
—
CDC:
“Clinical Presentation
Patients with MIS-C usually present with persistent fever, abdominal pain, vomiting, diarrhea, skin rash, mucocutaneous lesions and,
in severe cases, with hypotension and shock. They have elevated laboratory markers of inflammation (e.g., CRP, ferritin),
and in a majority of patients laboratory markers of damage to the heart (e.g., troponin; B-type natriuretic peptide (BNP) or proBNP).
Some patients develop myocarditis, cardiac dysfunction, and acute kidney injury. Not all children will have the same signs and symptoms, and some children may have symptoms not listed here. MIS-C may begin weeks after a child is infected with SARS-CoV-2. The child may have been infected from an asymptomatic contact and, in some cases, the child and their caregivers may not even know they had been infected.”
Multisystem Inflammatory Syndrome in Children (MIS-C)
—
ETA: My final assessment after posts above indicate that IMO, as a result of MASSIVE family travel and gatherings over Thanksgiving, as well as an already severely escalated Covid situation, there is very likely IMO going to be a surge of children, and babies, who will get very ill, have potential long term effects, and some (more) will die. Again, this is not something we are seeing a lot of talk about (yet), but wait for it, imo. This is very upsetting, especially considering much will occur due to disinformation and outright disregard, which could have been prevented.
Yesterday I mentioned the guilt that some may later feel for infecting their family members as a result of Thanksgiving travel - well, I now revise this to include guilt over their children who, as seen above, could become sick and die as a result - “rare” or not. Again, what does one consider “rare” - there comes a point where even a small percentage results in a large number when there is this much community spread. IMO, with increasing cases, this will become “not as rare” as previously described, simply due to increased spread/prevalence, jmo.
