Covid-19 Vaccine Development

[margarita25]

2 days ago:

 

[margarita25]

December 9, 2020: “Tonight the new warning on Pfizer’s COVID vaccine with FDA approval potentially hours away...”

From the above video, “2 nurses showed allergic anaphylactoid reactions/ Most commonly rashes and shortness of breath, different from anaphylaxis, which can be fatal - both have a history of serious allergies, carry epipens, and recovered quickly. What caused the allergic reactions is unclear. The most common triggers in vaccines, preservatives, animal products, are not in the Pfizer vaccine.”...UK regulatory guidance: “People with significant allergies to food, medications or vaccines should not take the Pfizer.”

 

[gngr~snap]

Then there this:
For people with immune deficiency.
COVID-19 vaccines and PID

 

[BetteDavisEyes]

From the above video, “2 nurses showed allergic anaphylactoid reactions/ Most commonly rashes and shortness of breath, different from anaphylaxis, which can be fatal - both have a history of serious allergies, carry epipens, and recovered quickly. What caused the allergic reactions is unclear. The most common triggers in vaccines, preservatives, animal products, are not in the Pfizer vaccine.”...UK regulatory guidance: “People with significant allergies to food, medications or vaccines should not take the Pfizer.”

This is precisely the reason that I won't be rushing to get any vaccine until they are determined to be safe and effective. At this juncture, I'm not convinced that there has been sufficient study of the various vaccines. JMO

 

[margarita25]

Live:

 

[margarita25]

Coronavirus live updates: FDA panel considers Pfizer vaccine one day after U.S. reports record 3,140 deaths

 

[IceIce9]

The hospital system where I am employed has put a plan in place for giving the vaccines.

Some of the details:

Stored at 90 degrees below zero, vaccine vials must be transported to the two designated vaccination sites in dry ice. The container door cannot be opened for longer than 15 seconds. Vaccine vials must be thawed, then reconstituted. Must be given within 6 hours of thawing or be discarded.

This is more involved than giving a usual injection, such as flu or tetanus. My suggestion is that you should receive a COVID vaccine from someone very experienced n giving vaccines. I know many companies hire temporary staff to run flu shot clinics, and some of these staff members might only have experience in giving flu shots.

 

[IceIce9]

I am concerned about the amount of training (or lack of training) giving to some who will be giving the vaccine. I personally have received quite a few emails from companies who are hiring temporary employees for COVID vaccinating.

One email I received began, “CVS is hiring thousands of employees to staff COVID vaccine administration clinics....”

 

[dixiegirl1035]

Vaccines: Updated with J&J information last week, and 12/10 updated with Moderna now adding down to 12 years to compete/meet what Pfizer did originally for that age.

Roll outs
Moderna/NIH 20 million doses ready by end of 2020; 500 million to one billion doses in 2021. Can be manufactured in US, Switzerland and Spain. Advanced orders are US order was for 100 million doses with options on 400 million more (US gave nearly $1 billion in support) ; EU 80 million doses then 80 million more; Japan 50 million doses; Canada 20 million; Switzerland 4.5 million; UK 5-7 million doses for spring. They are in talks with WHO, COVAX re distribution and a tiered pricing proposal.
Cost expected $32-37/dose Tested on 18 Years old and up
UPDATE 12/10/2020: Adding down to 12 years old on 12/10/2020 for future trial Moderna Announces First Participants Dosed in Phase 2/3 Study of COVID-19 Vaccine Candidate in Adolescents | Moderna, Inc. and Moderna begins testing coronavirus candidate vaccine in US teens | fox61.com

Pfizer 50 million doses by end of 2020. Advanced orders are US 100-500 million; EU 200 million; UK 40 million doses
Cost expected $19.50/dose Tested on 12 years old and up

AstraZeneca/Oxford
EU 400 million doses; UK 100 million doses; alliance for poorer countries 300 million doses. (Need info on US...)
Cost expected $5/dose Tested on 5-12 years old and 18 and up

Sanofi and GlaxoSmithKline
No info on.
Cost expected $12/dose

Johnson & Johnson
US $1billion for 100 million doses, EU 200 million doses, production 1 billion doses in 2021. (per 12/4 Dr. Campbell video) - Note: They started out in September with 1 dose trial of 60k, and a second phase 3 trial with 2 doses began on November 16th

Source:
Coronavirus COVID-19 - Global Health Pandemic #87

Coronavirus COVID-19 - Global Health Pandemic #87

I had never read this before... information on operation Warp Speed which I found of interest much of the info.
Fact Sheet: Explaining Operation Warp Speed

This document has lots of information as to priorities of vaccines and who gets and when that I've never heard in MSM. I found the document very educational. More specifics from this past week though.

https://www.cdc.gov/vaccines/imz-ma...D-19-Vaccination-Program-Interim_Playbook.pdf[/QUOTE]

 

[CSIDreamer]

I am concerned about the amount of training (or lack of training) giving to some who will be giving the vaccine. I personally have received quite a few emails from companies who are hiring temporary employees for COVID vaccinating.

One email I received began, “CVS is hiring thousands of employees to staff COVID vaccine administration clinics....”

Can you explain your concerns? I know you're in HC and trust your opinion.

 

[CrimeAway]

I know that there have been cases of shoulder injury from incorrect administration of other IM vaccines that are regularly given into the deltoid muscle.

shoulder injury related to vaccine administration - Google Search

It has to be easier (IMO) than administering SQ vaccines to the legs of VERY wiggly puppies and kittens though ;-)

 

[IceIce9]

Can you explain your concerns? I know you're in HC and trust your opinion.

Most vaccines (flu, tetanus, hepatitis, etc) are in prefilled syringes. They are a premeasured dose. All that is required from the nurse or other healthcare worker is to attach the correct size of needle and give the vaccine. No measuring, mixing, reconstituting. Relatively foolproof for healthcare workers.

In quite a few states, medical assistants, phlebotomists, pharmacists and other healthcare professionals are allowed to give vaccine injections. There is no set amount of training or level of certification that allows a healthcare professional to give vaccines. You don’t have to be a nurse in order to give vaccines.

Pfizer COVID vaccines, however, are not going to come in prefilled, premeasured syringes. They are in vials that have to be stored at 90 degrees below zero. When the vials are retrieved from frozen storage the door has to be closed within 15 seconds.

The vials have to thaw. Then the healthcare worker needs to draw up the correct measurement of vaccine into a syringe, inject the vaccine into the correct amount of sterile water to reconstitute, mix it up, and draw it back into the syringe. Then the correct needle needs to be attached to the syringe and the injection can be administered.

The thawed vaccine must be used within 6 hours or it must be discarded.

There are several steps to the process, and lots of room for error including incorrect measurement and leaving the thawed vaccine out too long.

I conduct orientation classes including skills check offs, as well as annual clinical inservices and trainings for nurses and other clinical staff. I know that many are very inexperienced with any vaccines that aren’t in prefilled syringes. I also handle the coaching sessions and retraining for nurses and other clinical personnel and I can tell you that injection errors are very common.

With the amount of medical staff that will be needed to administer the huge demand for COVID vaccines, I am concerned that there is potential for errors. If vaccine errors are made, people who have received COVID vaccines might be unprotected, because they would be unaware vaccine was given incorrectly.

 

[dmac55]

deleted by me

 

[dmac55]

deleted by me
Errors left and right;/

 

[anneg]

Most vaccines (flu, tetanus, hepatitis, etc) are in prefilled syringes. They are a premeasured dose. All that is required from the nurse or other healthcare worker is to attach the correct size of needle and give the vaccine. No measuring, mixing, reconstituting. Relatively foolproof for healthcare workers.

In quite a few states, medical assistants, phlebotomists, pharmacists and other healthcare professionals are allowed to give vaccine injections. There is no set amount of training or level of certification that allows a healthcare professional to give vaccines. You don’t have to be a nurse in order to give vaccines.

Pfizer COVID vaccines, however, are not going to come in prefilled, premeasured syringes. They are in vials that have to be stored at 90 degrees below zero. When the vials are retrieved from frozen storage the door has to be closed within 15 seconds.

The vials have to thaw. Then the healthcare worker needs to draw up the correct measurement of vaccine into a syringe, inject the vaccine into the correct amount of sterile water to reconstitute, mix it up, and draw it back into the syringe. Then the correct needle needs to be attached to the syringe and the injection can be administered.

The thawed vaccine must be used within 6 hours or it must be discarded.

There are several steps to the process, and lots of room for error including incorrect measurement and leaving the thawed vaccine out too long.

I conduct orientation classes including skills check offs, as well as annual clinical inservices and trainings for nurses and other clinical staff. I know that many are very inexperienced with any vaccines that aren’t in prefilled syringes. I also handle the coaching sessions and retraining for nurses and other clinical personnel and I can tell you that injection errors are very common.

With the amount of medical staff that will be needed to administer the huge demand for COVID vaccines, I am concerned that there is potential for errors. If vaccine errors are made, people who have received COVID vaccines might be unprotected, because they would be unaware vaccine was given incorrectly.

Thank you for your detailed comments. It seems that vaccination with the Pfizer vaccine will be a complex process with various opportunities for errors. I find this rather scary!

 

[IceIce9]

Thank you for your detailed comments. It seems that vaccination with the Pfizer vaccine will be a complex process with various opportunities for errors. I find this rather scary!

I don’t mean to discourage anyone from getting the vaccine. My recommendation is that you get it from an experienced healthcare professional.

 

[anneg]

I don’t mean to discourage anyone from getting the vaccine. My recommendation is that you get it from an experienced healthcare professional.

Yes, thank you. We have a CVS near us so we may get it there. Or perhaps our doctors' office will be able to vaccinate us. I think it will probably be at least April before we can get vaccinated, even though we are in a high-risk group (over 75).

 

[anneg]

US FDA panel recommends Covid-19 vaccine authorization

https://www.cnn.com/world/live-news/coronavirus-pandemic-12-10-20-intl/h_290b4cb2182bba9d1196420e3125d324

FDA committee vote to recommend EUA for Pfizer’s vaccine is "important," Fauci says

 

[10ofRods]

Yes, thank you. We have a CVS near us so we may get it there. Or perhaps our doctors' office will be able to vaccinate us. I think it will probably be at least April before we can get vaccinated, even though we are in a high-risk group (over 75).

Do contact your doctor. I am hoping you will be prioritized before April.

A lot of people who are prioritized are not going to show up for their vaccines, so you want to keep pushing to get yours sooner. Your doctor and their office should be able to help you with this.

All it takes is a prescription.

 

[anneg]

Do contact your doctor. I am hoping you will be prioritized before April.

A lot of people who are prioritized are not going to show up for their vaccines, so you want to keep pushing to get yours sooner. Your doctor and their office should be able to help you with this.

All it takes is a prescription.

Yes, I hope we can get it sooner, too. Although I'm concerned about the allergy issue. DH is allergic to some medications, the iodine contrast agent used for CT scans, and some other things like certain food dyes. I'm sure he will be consulting with his regular doctor and his allergist about the vaccine.