They have barely given those twins a thought, IMO, except as props for photo shoots. I don't think they ever gave the kids much more than a thought. I think they are extremely selfish and I think they had those children to use as accessories, like a purse or a hat: "Look at our kids!" I don't know for sure what happened to Madeleine but I think the parents know more than they are saying...and I do find it curious, as someone has posted, that we've heard nothing at all from the friends they were traveling with, on any of it.
I think it's time they pack it in, go home to England, and try to put a little normalcy and more attentive parenting into the twins' little lives while they do what they can from England to try and find Maddie, but I think the reality is, she is gone forever. And Kate, if you're going to quit being a doctor, do it to be a SAHM for your remaining children, not to travel some more and be an "advocate", b/c you and your husband are poster children for selfish, self-centered parents.