IMO education is the key. That education needs to begin at home.
Remember the "stranger danger" movement? When parents began teaching their kids it was not okay to take candy from strangers? As a result no child will allow a stranger to approach them, because parents pounded into their heads what happens to little kids who let a stranger near them. All the horror stories parents could think of went into their kids minds.
From the time your children understand start teaching them the horrible effects of drugs. Make them afraid to try it even one time. Preach at them over and over that all it takes is one pill to get addicted. Reinforce that all through the formative years that drugs are evil incarnate and just touching them can lead to death. Teach them that all doctors are not right. That if a doctor gives them pain pills make sure they are warranted and the lowest dose possible. Scare them so they never forget that drugs are death.
Get involved in your children's school. Make sure the teachers are reinforcing the message you are preaching to your kids at home.
IMO the increase in home schooling is the parents way of trying to control the bad things kids can be exposed to in school. The 100% control over their kids during the elementary stage in school is effective if used properly. Kids who are home schooled can score higher on SAT's and have lower rates of drug use. But it takes work on the part of the parents.
IMO a little bit of irrational fear in your kids is much better than losing them to a drug overdose.
Raisin, I went to nursing school at a hospital for chronic care patients and many of the patients were brain damaged due to overdosing on drugs but having been "saved" by extraordinary measures, they remained alive for years in comatose and semi-comatose conditions. It's a whole "world of it's own" that many are not even aware exists. For patient privacy issues, it can't be done, but if only some kids could see what drugs can do. These patients were trapped in their crumpled up bodies since they, too, were kids who just took too much, or took the wrong thing or took just a little even for the very first time. Some even ended up there because they tried to QUIT and suffered seizures as a result that permanently devastated their bodies and minds. If only kids knew but descriptions of those patients and how they "live" can't be imagined. I think I can honestly say that many of them would have preferred a final overdose and be done. That was in around 1976 and no doubt, nothing has changed. Those horrible places must still exist. We worry about overdose but there's really something much worse than that in store for some people. I wish people could be made aware of this! ... why is it kept as such a secret?