@fraize - I thought I'd let you know that several people have been noticing that we're having to click on a Reaction more than once to get it to stick. I noticed this a few months back. At first I thought I was losing my mind when a bunch of posts I KNEW I had Reacted to don't have a Reaction from me. Long story short... I've asked others in a small group if they've noticed and about half of them have, so... it's not just me. Something's going on.
Also, the others who have noticed thought it could be this issue or that, but none of what they were thinking are the issue (wireless, slow connectivity, and/or being on multiple devices) as none of those apply to me (I'm not wireless, I have fast connectivity, and I only have one device (desktop)).
FYI...