So, as the epithelial cells in the body are attacked by SARS-CoVid-2 causing CoVid19 disease, the veins and arteries react to their own bleeding by clotting, of course. Here's a fairly readable article on the clotting issue:
Coronavirus blood-clot mystery intensifies
And here again is the Lancet article about a potentially protective treatment (it was posted above and it involves interferon - which early on, was seen to be helpful all by itself). If you're keeping a folder of possible treatments to discuss with your doctors as this pandemic wears on, this is a good one to clip:
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31042-4/fulltext
^Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial.
This one is for
@otto and anyone else interested in the ongoing research that will really get us closer to a specific Covid19 treatment:
Disruption of the CCL5/RANTES-CCR5 Pathway Restores Immune Homeostasis and Reduces Plasma Viral Load in Critical COVID-19
^In that one, "the CCR5 blocking antibody leronlimab" was used in CV19 patients who were near death and basically on hospice, with good results.
And in this study, using machine-made antibodies (with technology similar to CRISPR), scientists were able to synthesize a monoclonal antibody for CoVid-19:
Antibody blocks infection by the SARS-CoV-2 in cells, scientists discover
That one is very promising and quite different from a typical vaccine.
For those of you interested in vaccines, in the US the "first phase" of testing involves finding about 40 people to vaccinate with the untested vaccine. These are typically doctors, laboratory scientists, lab techs and others who are already working around the virus or who can give very informed consent. Then wait 40 days, basically, and see if anyone dies. Note side effects.
Phase 2 involves exposing those same people to CoVid-19 to see if the vaccine works. With CV-19, I think the FDA is waiving some aspects of the usual time period, since CV-19 usually shows up within 3-10 days after exposure (if not a bit earlier). But anyway, the traditional wait is 6 weeks.
Can you imagine volunteering for that?
My understanding is that usually, after this phase, military personnel receive vaccines, starting with those in areas most at risk - then the wait begins, but now with a much more general population. I don't know how they ever work kids into these models, but I do know that at some university hospitals, where parents can be fully educated about the situation, children with immune insufficiency who desperately need a vaccine to continue to survive to adult life in a pandemic may be innoculated (but not exposed - just tested for antibodies).
In this case, the FDA may have made more changes to the regular protocol, it's something I need to dig into more, if anyone sees articles on this, please post!
........moo
