Coronavirus COVID-19 - Global Health Pandemic #72

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More on GB and CV/WebMD June 25:

June 25, 2020 -- The first official U.S. case of Guillain-Barré syndrome associated with COVID-19 has been reported by neurologists from Allegheny General Hospital in Pittsburgh, further supporting a link between the virus and neurologic complications.

As previously reported by Medscape Medical News, doctors in China reported the first case of COVID-19 that doctors at first thought was Guillain-Barré syndrome, or GBS. The patient was a 61-year-old woman returning home from Wuhan during the pandemic.

Doctors in Italy later reported five cases of GBS associated with COVID-19.

The first U.S. case is described in the June issue of the Journal of Clinical Neuromuscular Disease.

Unique Features
Like cases from China and Italy, the U.S. patient's symptoms of GBS reportedly occurred within days after he was infected with SARS-CoV-2, the virus that causes COVID-19.

U.S. Guillain-Barré Case Linked to COVID-19

Eta: I’m remembering more about this now:

post #730 by @dixiegirl1035 / Feb 21:
Coronavirus COVID-19 - Global Health Emergency #5


I also posted about it here in April:
Guillain-Barre Linked to COVID-19 in Italy
— Five patients developed GBS following COVID-19 infection

—-

It seems China put this out on April 9:
First case of COVID-19 presenting as Guillain-Barré reported



“GBS presentation
The female patient returned from Wuhan on January 19 but denied having any fever, cough, chest pain, or diarrhea. She presented on January 23 with acute weakness in both legs and severe fatigue that progressed.

At presentation, temperature was normal, oxygen saturation was 99% on room air, and the patient’s respiratory rate was 16 breaths per minute. She was not tested for SARS-CoV-2 at that point.

A neurologic examination revealed symmetric weakness (Medical Research Council grade 4/5) and areflexia in both legs and feet. The patient’s symptoms had progressed 3 days after admission, and testing revealed decreased sensation to light touch and pinprick.

Admission laboratory test results indicated a low lymphocyte count and thrombocytopenia. Results of nerve conduction studies performed on day 5 of hospitalization were consistent with demyelinating neuropathy.

She was diagnosed with GBS and given intravenous immunoglobulin. On day 8, she developed a dry cough and fever, and a chest CT showed ground-glass opacities in both lungs. At this point, she was tested for SARS-CoV-2, and the results were positive.”

—-
June 24:
First Reported US Case of Guillain-Barré Linked to COVID-19

“"Although the number of documented cases internationally is notably small to date, it's not completely surprising that a COVID-19 diagnosis may lead to a patient developing GBS. The increase of inflammation and inflammatory cells caused by the infection may trigger an irregular immune response that leads to the hallmark symptoms of this neurological disorder," Rana said in a news release.

"Since GBS can significantly affect the respiratory system and other vital organs being pushed into overdrive during a COVID-19 immune response, it will be critically important to further investigate and understand this potential connection," he added.“

Remember the two couples who were posting at the same time as David and Sally Abel from the Princess. One of the guys of the other two couples that got back to the states vs. hospitalized like David and Sallay had Guillain-Barré at the time and was taken off in a wheelchair that we posted at the time.

He's having a very difficult time again.
 
That was my first thought. My young Niece had it. She walked in to a routine dental exam, Mom drove her home and she couldn't get out of the car. Straight to Hospital and this was her diagnosis. She still has a foot that drags a bit when tired or doing stairs. She is only 13 years old.

Can that lay dormant? I know nothing about it.
 
OMG

“But on July 16, he stopped breathing.

Doctors rushed to put Silva on a ventilator and by Saturday night, he was flown to Massachusetts General Hospital from Tampa, Florida on a private intensive care jet with hopes of treating a rare infection that has left him paralyzed from the neck down, Boston25 News reported.

“They basically said it is COVID-related because it’s triggered by a viral infection,” Barbara Bonnet, Silva’s mother — a Massachusetts resident — told the station. “What happened is it laid dormant in my son’s system, still testing negative, still without any symptoms, but it was still there.”“

—-

Eta: Holy moly! What kind of “rare, (and viral) infection“?? :eek:

Do we have an any prior reference on this? @dixiegirl1035 I’m not recalling ever hearing about anything of the like?

Dunno, as folks don't put the exact diagnosis on the gimme page? So can't even speculate. Sorry no input until such.

ETA:

Guillain-Barre, maybe?

https://www.nejm.org/doi/full/10.1056/NEJMc2009191

ETA:
Bonnet told 25 News that Boston doctors have tentatively diagnosed her son with transverse myelitis — an inflammation of both sides of the spinal cord — but she’s hopeful he’ll make a full recovery soon.

Florida nurse flown to Boston hospital after COVID-19 left him paralyzed | Boston.com
 
There is a video here. Part of tonight's Aussie current affairs TV show called The Project. It has 4 different younger Aussie people (between 25 and 44 years old) who are speaking of their covid infection experience ... the illness they went through, and the after-effects, so far.

If you have a spare few mins - it's not long - it gives a really good overview of what happened to each of these people, where they think they caught the virus, the degree of their varied suffering ....

My bff's sister died yesterday in Florida. She was sick for only 3 days. :'(
whoosh...wow, that is hard. Did you get any explanation of why she succumbed so drastically and quick?

My best friends' son, a very healthy 50 year old health care practitioner, has a pretty bad case... 12 days and counting. So sick with vomiting, diarhea, headaches, cough.... but his temperature has been normal for 3 days now, and he is not having such terrible symptoms. But the absolute complete exhaustion can last for so much longer.
 
The shirt and shoes requirement for restaurants are Health Laws. They will stand up in a court of law, under a judge.

Masks are mandates, there is no law involved. Most local justifications don't have the time, money or enough officers to settle these disputes, not do they want to enter into them.

Each states has equal opportunity to pass emergency legislation. No state has used its power to put an end to the mask controversy. (To my knowledge) The most I've seen are fines for not wearing a mask. Doesn't seem to be working out for most states or localities.

MOO..
Do you have a link showing it is a health law?
 
Can that lay dormant? I know nothing about it.
Not sure. I know it hits fast and the further it travels upward the more devastation and even death. They try to stop it travelling with high doses of anti inflammatory. She had a ton of physical therapy. I pray she doesn't get Covid as I am not sure how this would play out for her. IIRC she was to avoid any virus moving forward. I worry for her as she is in the U.S.
ETA
Transverse myelitis - Symptoms and causes
 
OMG

“But on July 16, he stopped breathing.

Doctors rushed to put Silva on a ventilator and by Saturday night, he was flown to Massachusetts General Hospital from Tampa, Florida on a private intensive care jet with hopes of treating a rare infection that has left him paralyzed from the neck down, Boston25 News reported.

“They basically said it is COVID-related because it’s triggered by a viral infection,” Barbara Bonnet, Silva’s mother — a Massachusetts resident — told the station. “What happened is it laid dormant in my son’s system, still testing negative, still without any symptoms, but it was still there.”“

—-

Eta: Holy moly! What kind of “rare, (and viral) infection“?? :eek:

Do we have an any prior reference on this? @dixiegirl1035 I’m not recalling ever hearing about anything of the like?

This is just so frightening.... I so fear we are going to be hearing these nighmare cases for a long time... longterm effects may be worse than ever....

The article stated: diagnosis of transverse myelitis and that’s basically the inflammation of your spine..

A number of conditions appear to cause transverse myelitis, including:

  • Immune system disorders. These disorders appear to play an important role in causing damage to the spinal cord. Such disorders are:
    • aquaporin-4 autoantibody associated neuromyelitis optica
    • multiple sclerosis
    • post-infectious or post-vaccine autoimmune phenomenon, in which the body’s immune system mistakenly attacks the body’s own tissue while responding to the infection or, less commonly, a vaccine
    • an abnormal immune response to an underlying cancer that damages the nervous system; or
    • other antibody-mediated conditions that are still being discovered.
  • Viral infections. It is often difficult to know whether direct viral infection or a post-infectious response to the infection causes the transverse myelitis. Associated viruses include herpes viruses such as varicella zoster (the virus that causes chickenpox and shingles), herpes simplex, cytomegalovirus, and Epstein-Barr; flaviviruses such as West Nile and Zika; influenza, echovirus, hepatitis B, mumps, measles, and rubella.
 
This is just so frightening.... I so fear we are going to be hearing these nighmare cases for a long time... longterm effects may be worse than ever....

The article stated: diagnosis of transverse myelitis and that’s basically the inflammation of your spine..

A number of conditions appear to cause transverse myelitis, including:

  • Immune system disorders. These disorders appear to play an important role in causing damage to the spinal cord. Such disorders are:
    • aquaporin-4 autoantibody associated neuromyelitis optica
    • multiple sclerosis
    • post-infectious or post-vaccine autoimmune phenomenon, in which the body’s immune system mistakenly attacks the body’s own tissue while responding to the infection or, less commonly, a vaccine
    • an abnormal immune response to an underlying cancer that damages the nervous system; or
    • other antibody-mediated conditions that are still being discovered.
  • Viral infections. It is often difficult to know whether direct viral infection or a post-infectious response to the infection causes the transverse myelitis. Associated viruses include herpes viruses such as varicella zoster (the virus that causes chickenpox and shingles), herpes simplex, cytomegalovirus, and Epstein-Barr; flaviviruses such as West Nile and Zika; influenza, echovirus, hepatitis B, mumps, measles, and rubella.

I was just looking at some similar things.

Coexistence of myositis, transverse myelitis, and Guillain Barré syndrome following Mycoplasma pneumoniae infection in an adolescent
2013

—-

Eta: Alright, here we go:
Acute transverse myelitis associated with SARS-CoV-2: A Case-Report
June 6


Highlights
  • • The third case of acute transverse myelitis due to SARS-CoV-2 reported in the world.
  • • Possible inflammatory complications affecting the myelin in spinal cord.
  • • We must be vigilant of the critical neurological illnesses associated with COVID-19.

—-

Acute myelitis as a neurological complication of Covid-19: A case report and MRI findings
June 6

Abstract
During the recent outbreak of coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 coronavirus, there is rising concerns about neurological complications of COVID-19. Fever, headache, and anosmia may occur early during the disease course. Other neurological sequalae such as encephalitis may occur in later phases. We report a case of acute myelitis in a 32-year old male COVID-19 positive patient who presented with a 2-day history of flu-like symptoms then sudden onset paraplegia and urinary retention. The incidence is not known and the pathogenesis of the disease behind this manifestation is still not fully understood. Nevertheless considering the broad differential diagnosis of acute myelitis, prompt clinical, and diagnostic work up was crucial to exclude other causes. Patients presenting with neurological symptoms such as loss of consciousness, ataxia, convulsions, status epilepticus, encephalitis, myelitis or neuritis should raise concerns for COVID-19 infection during this pandemic prompting early diagnosis and initiation of proper management.
 
Last edited:
“We’ve stabilized at 95 miles an hour, and that is not the speed that we want to be going,” said Dr. Joshua LaBaer, director of the Biodesign Institute at Arizona State University. “Ideally, we don’t want this car moving at all.”

What Arizona’s Tenuous Coronavirus Plateau Could Teach Us
What Arizona’s Tenuous Virus Plateau Could Teach Us

(If you cannot access this New York Times article, I learned this from Websleuths about articles behind paywalls-
Type the title of the article into a Google Chrome incognito tab)

wow..gotta try this! thanks
 
This is just so frightening.... I so fear we are going to be hearing these nighmare cases for a long time... longterm effects may be worse than ever....

<RSBM>
<RSBM>
Patients presenting with neurological symptoms such as loss of consciousness, ataxia, convulsions, status epilepticus, encephalitis, myelitis or neuritis should raise concerns for COVID-19 infection during this pandemic prompting early diagnosis and initiation of proper management.


Neurologists are now looking at how much the virus affects the brain. A leading neurologist (at our Alfred Hospital, which is a leading teaching hospital) said that at first they were not looking at this, because the virus appeared to be a respiratory assailant. But with reports of strokes, seizures, psychosis, extreme fatigue and memory loss in younger people, they have now set up a study to research its effects on the brain.

They suspect the immune system may be attacking the brain, causing brain damage.

COVID attacks the brain | Alfred Health
 
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Could COVID-19 Trigger Chronic Disease in Some People?
July 17

“Although many of them may yet recover in the coming months, some scientists are becoming increasingly worried that some may end up with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a debilitating and poorly understood condition associated with some viral infections. In a press conference last week, for instance, National Institute of Allergy and Infectious Diseases Director Anthony Fauci noted that some of the long-haulers’ symptoms resemble those of ME/CFS. Studies are now underway to track whether some long-haulers develop the disease, and if so, to investigate its underlying mechanisms and possible avenues for treatment quickly.

“This is a massive infection of millions and millions of people. I think one has to be really concerned about the long-term consequences,” notes Avindra Nath, a neurovirologist at the National Institute of Neurological Disorders and Stroke. “A lot of emphasis early on has been on providing treatments and vaccines and antibodies and all that kind of stuff, but the long-term consequences have not received the attention that they deserve.”

Viral infections and ME/CFS...
More at link
 
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Our government here, Australia, had a big campaign re the seriousness of getting both the flu and the coronavirus at the same time and it seemed a lot of people did take notice. There was a huge run on the flu shots heading into our winter season. My first appointment to get it was cancelled when my medical centre ran out.
I ended up having it a week later.

That is not good. I've been wondering for a while what is going to happen this fall/winter when people contract covid and flu at the same time
 
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The shirt and shoes requirement for restaurants are Health Laws. They will stand up in a court of law, under a judge.

Masks are mandates, there is no law involved. Most local justifications don't have the time, money or enough officers to settle these disputes, not do they want to enter into them.

Each states has equal opportunity to pass emergency legislation. No state has used its power to put an end to the mask controversy. (To my knowledge) The most I've seen are fines for not wearing a mask. Doesn't seem to be working out for most states or localities.

MOO..

I watched a viral video yesterday of a fiasco in a big box store. The gal was saying "I can do anything I want, this is public property".

SMDH...

Nope lady, that is a big box store and therefore private property and is a business and you can be kicked out for trespassing as we saw. (lol, I loved a comment I read that said... "I'm going there to talk to the guy in plumbing about my constitutional right" or such being paraphrased.

Where do these folks live that they need to shout out such from? I really do believe that they are not only ignorant ( many of us are to many things MOO, that's not a slam as we just don't know all yet)... but they just want to pot stir for attention MOO on the obvious.

On social media.. FB etc... we have an ignore button... I use it. It saves soooooooooooo much time reading and scrolling these days!
 
Our government here, Australia, had a big campaign re the seriousness of getting both the flu and the coronavirus at the same time and it seemed a lot of people did take notice. There was a huge run on the flu shots. My first appointment to get it was cancelled when my medical centre ran out.
I ended up having it a week later.

Our

Yes, WHO expressed great concern about this also:

Director General / June 15:

“Despite the ongoing global response to the COVID-19 pandemic, we cannot lose sight of other significant public health issues, including influenza.

Influenza affects every country every year, and takes its own deadly toll.

As we enter the southern hemisphere influenza season and begin planning for the northern hemisphere season, we must ensure that influenza remains a top priority.

Co-circulation of COVID-19 and influenza can worsen the impact on health care systems that are already overwhelmed.

More than 500 million people are vaccinated against flu every year, based on recommendations from WHO on the composition of flu vaccines.

These recommendations are based on data and virus samples collected and analyzed by WHO’s Global Influenza Surveillance and Response System, or GISRS.

The GISRS system has been functioning since 1952 and I would like to thank the more than 125 countries that participate in it.

Over the past 8 years, significant strengthening of the system has been made possible through the Pandemic Influenza Preparedness Framework, and I would also like to thank the public and private sector partners that participate in this global system.

The infrastructure, people, skills and experience built up through GISRS, WHO Collaborating Centres, and national influenza centres have been the foundation for detecting COVID-19.

However, this well-established system is now seeing significant challenges.

Influenza surveillance has either been suspended or is declining in many countries, and there has been a sharp decline in sharing of influenza information and viruses because of the COVID-19 pandemic.

Compared with the last three years, we’ve seen a dramatic decrease in the number of specimens tested for influenza globally.

We’ve also seen a 62% decrease in the number of virus shipments to WHO Collaborating Centres, and a 94% decrease in the number of influenza viruses with genetic sequence data uploaded to the GISAID database.

These decreases are due to a combination of issues, including the repurposing of staff and supplies, overburdened laboratories, and transport restrictions.

These disruptions may have short- and long-term effects, such as the loss of capacities to detect and report new influenza viruses with pandemic potential.

As many of you know, twice a year WHO convenes a group of experts who together analyze the circulating flu strains. Based on their analysis they select the viruses that should be targeted by flu vaccines for the upcoming season in each hemisphere.

To know which viruses are circulating, WHO relies on information from countries reported through GISRS, which we use to make recommendations for the composition of influenza vaccines.

This will help us to prevent more severe cases of flu and more deaths.

WHO has published guidance on how to integrate surveillance for COVID-19 into routine influenza surveillance as an efficient way to track both of these important respiratory viruses.

This is not only cost-effective, it’s also essential for protecting the world against the next flu season.

The Southern Hemisphere flu season is already underway. There is no time to lose.”

source
 
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