Covid-19 Vaccine Development

[CSIDreamer]

FDA approves Moderna COVID-19 vaccine, shipments set to be delivered Sunday

Moderna arriving in my area today.

 

[NoSI]

Wanted to let you all know.... i received my 1st vaccine on Thursday and feel fine. Arm a little sore but otherwise fine with no fever, malaise etc. I work in healthcare so we started vaccinating last week.

 

[margarita25]

A Public Health Milestone: COVID-19 Vaccine Q&A With Meredith Allen, ASTHO’s Vice President for Health Security
December 17, 2020
State Public Health | ASTHO

 

[margarita25]

 

[margarita25]

 

[margarita25]

 

[margarita25]

(Courtesy of @sds71)


The U.S. government is close to a deal with Pfizer for up to an additional 100 million doses of its coronavirus vaccine, a source told CNBC's Meg Tirrell on Tuesday.

The deal could be announced as early as Wednesday, according to the source. The New York Times first reported the news.

Pfizer Nears Deal With U.S. Government for More Covid Vaccine Doses, Source Says

 

[Reasonable & Just]

Wanted to let you all know.... i received my 1st vaccine on Thursday and feel fine. Arm a little sore but otherwise fine with no fever, malaise etc. I work in healthcare so we started vaccinating last week.

That is great to hear! Thanks for sharing.

 

[margarita25]

(Courtesy of @sds71)

@MikeDelMoro (MSNBC)

NEWS: Trump administration announces new deal with Pfizer. The company will deliver “at least 70 million doses by June 30, 2021, with the balance of the 100 million doses to be delivered no later than July 31, 2021.

 

[CSIDreamer]

Kroger Health pharmacies, clinics to provide COVID-19 vaccine

 

[margarita25]

What you need to know about serious Covid-19 vaccine side effects | GMA

 

[margarita25]

(Courtesy of @10ofRods)

Suspicions grow that nanoparticles in Pfizer’s COVID-19 vaccine trigger rare allergic reactions | Science | AAAS

Some initial notes from the beginning of the article:

“Severe allergy-like reactions in at least eight people who received the COVID-19 vaccine produced by Pfizer and BioNTech over the past 2 weeks may be due to a compound in the packaging of the messenger RNA (mRNA) that forms the vaccine’s main ingredient, scientists say. A similar mRNA vaccine developed by Moderna, which was authorized for emergency use in the United States on Friday, also contains the compound, polyethylene glycol (PEG).

PEG has never been used before in an approved vaccine, but it is found in many drugs that have occasionally triggered anaphylaxis—a potentially life-threatening reaction that can cause rashes, a plummeting blood pressure, shortness of breath, and a fast heartbeat. Some allergists and immunologists believe a small number of people previously exposed to PEG may have high levels of antibodies against PEG, putting them at risk of an anaphylactic reaction to the vaccine.”

[...]

“Anaphylactic reactions can occur with any vaccine, but are usually extremely rare—about one per 1 million doses. As of 19 December, the United States had seen six cases of anaphylaxis among 272,001 people who received the COVID-19 vaccine, according to a recent presentation by Thomas Clark of the U.S. Centers for Disease Control and Prevention (CDC); the United Kingdom has recorded two. Because the Pfizer and Moderna mRNA vaccines use a new platform, the reactions call for careful scrutiny, says Elizabeth Phillips, a drug hypersensitivity researcher at Vanderbilt University Medical Center who attended an NIAID meeting on 16 December. “This is new.”

News reports about the allergic reactions have already created anxiety. “Patients with severe allergies in the US are getting nervous about the possibility that they may not be able to get vaccinated, at least with those two
vaccines,” Togias wrote in an invitation to meeting participants. “Allergies in general are so common in the population that this could create a resistance against the vaccines in the population,” adds Janos Szebeni, an immunologist at Semmelweis University in Budapest, Hungary, who has long studied hypersensitivity reactions to PEG and who also attended the 16 December gathering.

Scientists who believe PEG may be the culprit stress that vaccination should continue. “We need to get vaccinated,” Phillips says. “We need to try and curtail this pandemic.” But more data are urgently needed, she adds: “These next couple of weeks in the U.S. are going to be extremely important for defining what to do next.””

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Also referenced in above article:

Risk of anaphylaxis after vaccination in children and adults

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Here is the CDC Report referenced above:

Anaphylaxis Following m-RNA COVID-19 Vaccine Receipt
Thomas Clark, MD, MPH December 19, 2020

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UK Government Press Release linked above:

Press release
Confirmation of guidance to vaccination centres on managing allergic reactions following COVID-19 vaccination with the Pfizer/BioNTech vaccine
Statement by Dr June Raine, Chief Executive of the Medicines and Healthcare products Regulatory Agency on the guidance to vaccination centres on managing allergic reactions following COVID-19 vaccination with the Pfizer/BioNTech vaccine

Published 9 December 2020

 

[margarita25]

U.S. plans to study allergic reactions from Pfizer's Covid vaccine
Monday, Dec. 21, 2020
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Pfizer COVID-19 vaccine causing more allergic reactions than expected
Dec. 24, 2020

“Alkis Togias, chief of the NIAID’s Allergy, Asthma, and Airway Biology Branch, told CNBC that “several hundred people” who have a history of severe allergic reactions will be involved in a study.”
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Moderna COVID-19 vaccine causes swelling and inflammation in patients who have cosmetic facial fillers
Thursday, December 24, 2020 1:18PM

“The FDA advisory committee reviewing the new Moderna vaccine has noted a specific side effect involving several trial participants who have cosmetic facial fillers.“

[...]

"”In these cases the patients all had swelling and inflammation in the area that was given the filler. A couple of the patients had cheek filler six months prior to their vaccine and one patient had lip filler done two days after the vaccine. All were treated with steroids and anti-histamines and all of their reactions resolved," she said.“

 

[margarita25]

Moderna COVID-19 vaccine causes painful side effects in patients who have facial fillers

 

[margarita25]

 

[margarita25]

Covid: Post-exposure antibody protection trialled
Dec. 25, 2020

“The experimental jab is being offered to people who have been in close contact with a confirmed Covid-19 case within the past eight days.

If it proves effective, it could protect vulnerable people who haven't yet been, or can't be, vaccinated.

And it could help to contain outbreaks.

The trial, run at University College London Hospitals (UCLH) NHS Trust, is looking at whether an injection of two different antibodies could prevent someone who has been exposed to Covid from developing the disease - or at least from becoming very ill.“

 

[anneg]

Covid: Post-exposure antibody protection trialled
Dec. 25, 2020

“The experimental jab is being offered to people who have been in close contact with a confirmed Covid-19 case within the past eight days.

If it proves effective, it could protect vulnerable people who haven't yet been, or can't be, vaccinated.

And it could help to contain outbreaks.

The trial, run at University College London Hospitals (UCLH) NHS Trust, is looking at whether an injection of two different antibodies could prevent someone who has been exposed to Covid from developing the disease - or at least from becoming very ill.“

This sounds very promising. I think this article is about the same thing:
AstraZeneca starts new COVID-19 prevention trials of antibody cocktail

The trial, run at University College London Hospitals (UCLH) NHS Trust, is looking at whether an injection of two different antibodies could prevent someone who has been exposed to Covid from developing the disease - or at least from becoming very ill.

Vaccines take weeks to offer full protection, meaning it's too late for them to be given once someone already has the virus brewing in their system.

But this monoclonal antibody treatment, developed by the drugs company AstraZeneca, should work to neutralise the virus immediately.

And it gives ongoing protection for up to a year.

It could mean healthcare workers, hospital patients and care home residents could be given the treatment if they have been exposed to a known Covid case.

[more at link]

 

[margarita25]

“Mass vaccination programs began to be rolled out across Europe on Sunday after several countries reported cases of a more contagious variant of coronavirus.

On what some have dubbed "V-Day," Germany, France, Italy, Portugal and Spain began inoculations, starting out with health workers and those most at risk of contracting the disease.

The coordinated vaccination campaign of unprecedented scale in the European Union, home to almost 450 million people is a crucial step in curbing the global pandemic.“

Mass coronavirus vaccination begins for 450 million across Europe

 

[margarita25]

AstraZeneca: Shot will be effective against COVID-19 variant

“LONDON (AP) — The head of drugmaker AstraZeneca, which is developing a coronavirus vaccine widely expected to be approved by U.K. authorities this week, said Sunday that researchers believe the shot will be effective against a new variant of the virus driving a rapid surge in infections in Britain.

AstraZeneca chief executive Pascal Soriot also told the Sunday Times that researchers developing its vaccine have figured out a “winning formula” making the jab as effective as rival candidates.

Some have raised concern that the AstraZeneca vaccine, which is being developed with Oxford University, may not be as good as the one made by Pfizer already being distributed in the U.K. and other countries. Partial results suggest that the AstraZeneca shot is about 70% effective for preventing illness from coronavirus infection, compared to the 95% efficacy reported by Pfizer and its German partner BioNTech.“

 

[margarita25]

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Germany mass vaccination program / Brazil yet to approve a vaccine