Apuzzo, an accountant in Yale's Department of Pharmacology, told CNN affiliate WFSB that Le was conscientious, energetic and "very excited" about getting married.
Contacted via e-mail by CNN, Apuzzo declined to comment, saying her superiors had
asked her to refer all media inquiries to the university's public affairs office.
She did, however, forward a letter sent by Yale University Police Chief James Perrotti to all faculty, students and staff.
The letter states Yale police, the FBI, Connecticut State Police and New Haven police are investigating Le's disappearance. Her friends, colleagues, family members and fiance are assisting police, the letter said.