Multisystem inflammatory syndrome in children (MIS-C and COVID-19)

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Notable Heroes in Health Care: Multisystem Inflammatory Syndrome in Children (MIS-C) team

 

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Metro doctors warn of rise in MIS-C cases, illness linked to COVID-19 among children / Dec 7, 2020
50% of all cases were reported In November alone, according to Douglas County Health officials

“"I would say more cardiac involvement and GI, your gut, but it can involve the kidney, it can involve the lung and it can involve the bone marrow and blood," said Dr. Alice Sato, an infectious disease expert with Children's Hospital.“

[...]

“According to Dr. Sato, the number of MIS-C cases is proportional to the number of COVID-19 cases. She's urging people to follow all safety precautions to protect kids from the inflammatory syndrome.”

 

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New MIS-C numbers show an increase in confirmed cases
Dec. 9, 2020

“Louisiana is inching closer to 100 confirmed MIS-C cases.“

 

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COVID-19 related condition found in kids showing up more, doctor says
December 15, 2020

“A doctor at Cincinnati Children’s Hospital says they are seeing more and more cases of COVID-19 related condition in kids and younger children.“

[...]

““We don’t entirely know what causes it, but we think that somehow the immune response that children have to COVID sets them up for this potentially life-threatening inflammatory reaction,” Dr. Schulert said.“

 

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Post-infectious inflammatory disease in MIS-C features elevated cytotoxicity signatures and autoreactivity that correlates with severity
Dec. 10, 2020

 

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Higher SARS-CoV-2 antibody titers in patients hospitalized with MIS-C
Nov. 17, 2020

“This study aimed to characterize SARS-CoV-2 serology in hospitalized patients with MIS-C at a children’s hospital in Atlanta. Researchers found that children with MIS-C had higher SARS-CoV-2 antibodies than those with COVID-19, Kawasaki disease (KD), and hospitalized controls. Higher levels of antibodies were associated with elevated ESR and prolonged length of hospital and ICU admission. While the widespread applicability of the study is limited by its small sample size, these findings may have diagnostic and prognostic value in MIS-C risk stratification and distinguishing it from other similar diseases.“

 

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“Your children are not safe when it comes to COVID-19. That's a message from medical experts who say, this country's cases of Multisystem Inflammatory Syndrome in Children are the highest in the Caribbean.“

T&T MIS-C Cases Highest In The Caribbean
Dec. 10, 2020

 

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South Africa:
https://www.capetownetc.com/news/western-cape-confirms-35-cases-of-mysterious-child-illness/
Dec. 14, 2020

“While accurate numbers for private centres and other state hospitals are not readily available, Chris Scott, an associate professor at the Red Cross War Memorial Children’s Hospital and Paediatric Rheumatology’s head of division confirms that Tygerberg Hospital is facing roughly 35 cases. The cases range in severity.“

 

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Mucocutaneous Manifestations of Multisystem Inflammatory Syndrome in Children During the COVID-19 Pandemic - Docwire News
Dec. 9, 2020

 

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SARS-CoV-2 May Damage Kids' Blood Vessels
Dec. 14, 2020

 

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NIH observational study of coronavirus infection and multisystem inflammatory syndrome in children begins
Dec. 16, 2020

“An observational study has launched to evaluate the short- and long-term health outcomes of SARS-CoV-2 infection in children, including multisystem inflammatory syndrome in children (MIS-C), and to characterize the immunologic pathways associated with different disease presentations and outcomes. SARS-CoV-2 is the virus that causes COVID-19. The study, called the Pediatric Research Immune Network on SARS-CoV-2 and MIS-C (PRISM), will enroll at least 250 children and young adults ages 20 years or younger from diverse racial and ethnic backgrounds at approximately 20 sites nationwide. The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, is sponsoring and funding the study. The PRISM study is part of a research effort led by NIH’s National Heart, Lung, and Blood Institute and Eunice Kennedy Shriver National Institute of Child Health and Human Development to understand MIS-C.“

 

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Primary Children’s Hospital co-leading a national study on serious COVID-19 syndrome in kids
Dec. 15, 2020

“Doctors at Intermountain Primary Children’s Hospital are seeing several young patients with the multisystem inflammatory syndrome in children, or MIS-C, a severe complication from COVID-19.“

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“The study is enrolling about 600 children from the United States and Canada through the Pediatric Heart Network, a pediatric research consortium created and funded by the NIH’s National Heart, Lung, and Blood Institute. Study participants are children who have been diagnosed with MIS-C and recovered, and who will become infected over the next two years.

The study will be conducted in more than 30 academic institutions across the United States and Canada.”

 

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'Most helpless feeling in the world': McLean mom reflects on daughter contracting MIS-C
Dec. 3, 2020

““We don't know the long-term complications of that," Levorson explained. "We don't know if they're going to have problems in the future, and so we need to watch these children very closely to know.”“

 

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These Neurologists Dealt with COVID-19 in So Many Different Ways
Their Most Valuable Lessons Learned
Dec. 17, 2020

“We now know that this virus, SARS-CoV-2, is much more ‘infectious’ than we originally thought—one person with COVID-19 is able to spread the virus easily to up to three or four additional people. We have also come to understand that children are not entirely immune from serious effects of the virus, as demonstrated by multisystem inflammatory syndrome in children (MIS-C), which can cause grave and life-threatening diseases in young children.“

 

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Three-Year-Old Boy Hospitalized with Rare Syndrome Linked to COVID-19
Nov. 30, 2020

““These kids would probably die if they didn’t come to the hospital,” she said.

The syndrome can cause problems with heart muscles and coronary arteries. Children with the condition are told not to return to organized athletics for six months. Siomos said Warren was fortunate not to suffer severe coronary dilation, and had no aneurysms, but doctors will continue monitoring his heart for an extended period.

“We’ll have to watch him for a long time,” she said.”

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“”We should have a humble approach to this virus and realize we don’t know everything, and understand we might find out even more — it could be good or it could be bad — but we need to protect each other,” she said.“

 

[margarita25]

Re: the new UK variant:

2:11 - “Key government scientists expressing higher confidence that a new coronavirus strain is more transmissible, 50% more infectious they now estimate, and they say there is a hint it more easily infects children.”

 

[margarita25]

For reference, courtesy of @pocketaccent:

"About 10% of asymptomatic children brought to L.A.-area campuses to get tested for the coronavirus over the past week were positive, the Los Angeles Unified School District announced Monday."

LAUSD: 1 in 10 asymptomatic children tested positive for the coronavirus | KTLA

 

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Delayed acute myocarditis and COVID‐19‐related multisystem inflammatory syndrome
Oct. 26, 2020

Subtle Cardiac Troubles in MIS-C Paint a 'Myocarditis-Like Picture'

The Striking Similarities of Multisystem Inflammatory Syndrome in Children and a Myocarditis-like Syndrome in Adults: Overlapping Manifestations of COVID-19

 

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NIH funds 8 new studies on COVID-19 related MIS-C in children

 

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NIH funds 8 new studies on COVID-19 related MIS-C in children