Having followed this off and on for years I think this is likely a tragic set of events. Maura obviously had plans, she looked for a place to stay, found none and to the knowledge of investigators went north with no booked lodging. She didn't drain her account though she had little, she took some of her studies, so suicide doesn't seem likely despite Fred's comment of the Squaw walk and climbing to a mountaintop to drink and die. I do feel Fred knew more about Maura's emotional state than he has ever been forthcoming with due to the " Squaw walk" comment.
I think its safe to say Maura was likely under a lot of stress and I think her whole idea was to take a break and take account of her life. Maura had been in an accident a few days before leaving and did substantial damage to Fred's new car, it appears alcohol may have been involved though she wasn't charged. Now Maura is in Swiftwater and has what appears to be a second alcohol related accident, Maura panics and flees the scene, not uncommon.
The search doesn't begin until a couple days later, what I believe is error number one, they used a glove that may not have been worn by Maura as a reference for the dog. Problem number two, they use an air scent dog and not a ground scent dog. Air currents have diluted the trail as well as contamination from numerous sources. No one saw a car stop and pick her up and there were houses in the immediate area.
Error three, they limited the search and focused mainly on the direction the car had come from, toward rt 302 and a couple roads off rt 112.
A witness came forward some weeks later and claimed to have seen what appeared to be Maura about 7 miles east of the accident scene and the subject went out of their way to avoid being seen said to have ducked out of sight when his lights caught who ever it was. This is a desolate road, and at this time of year no one is going to be walking it for the fun of it.
Maura had no cell reception, this is a vast cell dead zone. Maura had been drinking and took the alcohol with her which show's intent to consume. Lets assume Maura is now in a highly charged emotional state, 2 accidents days apart, she likely felt guilt about wrecking Dads car, feels like a loser and now has accident number two. Maura it seems may have also had other emotional baggage before all this.
Its cold, she's not properly dressed for the elements, she may have been running which promotes sweat, her alcohol content though unknown isn't helping the situation. This is a perfect recipe for hypothermia which cause's one to turn delusional and death isn't far.
In a delusional state of hypothermia people do bizarre things, like strip down though freezing, and wander off. Maura may have gone to a higher point to try to get phone reception and twisted an ankle or even broke a leg and perished.
This is desolate, extremely thick in vegetation and most of these woods are untraveled by man. If Maura did perish out there the real shock would be that she was found! I feel 75% or more, the case is she sadly perished of her own doing brought on by a highly charged state of emotion. When people are emotionally charged they do not think rationally, add alcohol and you easily have disaster. Maura's mother was ill and died, I find it hard to believe if Maura was alive and well she would let friends and family suffer all these years and not say goodbye to her mother.