Brian disappeared April 1, 2006. His last known location was the Ugly Tuna Saloona. There is not a single shred of evidence he ever left the building housing the bar, nor is there even a single legitimate indication - cell phone, credit card, atm card, car, apartment, surveillance cam, visual sighting, anything - of his ever subsequently being present anywhere outside the building housing the bar.
From the local NBC affiliate NBC4, April 5, 2006:
Meredith Reed, a friend who was with him that night in the bar, was one of the last friends to talk to Brian Shaffer. "Clint and Brian were talking about something, and
Brian mentioned he was going to go up, like toward the stage area," Reed said. After that, he apparently left, and has not been seen since.
From the local NBC affiliate NBC4, April 10, 2006:
Clint Florence is the last person to see Brian Shaffer. The two used to live together and were out celebrating the beginning of spring break. Florence described Shaffer as popular, but a bit of a loner. "Brian likes to either see somebody that he knows or wants to talk to the band. He is known to walk off. He just liked to walk off and do his own thing," Florence said. Florence described the timeline of the night Brian Shaffer disappeared. The men headed to the Ugly Tuna at about 9:15 p.m. At about 10:30 p.m., Brian Shaffer spoke to his girlfriend over the phone, Florence said. About 30 minutes later, the men walked to the Short North Tavern, where they had a few drinks. At 11:40 p.m., they walked to another bar. Then, at about 1:15 a.m., they returned to the Ugly Tuna. Florence said while he was drinking, Brian Shaffer periodically walked away to talk with some people he knew. "Brian got up with them. I am assuming he got up with them, walked out with them to talk with them on the foyer before going on the escalator," Florence said. Shaffer was last seen on surveillance cameras at about 2 a.m. "I called him that night and it went straight to voicemail. It was about 2 a.m. and (there was) no answer," Florence said. Florence said he doesn't think Shaffer had a nervous break down. "I am afraid that Brian might have left the bar and ran his mouth a little bit. He has been known to do that," Florence said. At closing time, after looking for Shaffer, Florence said he went home with another friend. "Of course, I regret now leaving, but I didn't think anything of it. I didn't think Brian -- that anything happened to him because he is known to walk away," Florence said.
From Columbus Monthly 2014 article:
Grainy footage shows Brian standing at the top of the escalator outside the Ugly Tuna Saloona a little after 1 a.m. on the morning of April 1, 2006, talking to two women whom his friend, Clint Florence, knew from Ohio State. After the two women leave, he walks back inside the bar.
Florence and another woman they were with told police later they had seen Brian after he’d returned to the bar and told him they were getting ready to leave. Then they lost track of him. After scanning the bar for Brian, calling him repeatedly and waiting for him outside, they left, assuming he had gone home without telling them.
http://www.columbusmonthly.com/content/stories/2014/09/when-missing-persons-cases-go-cold.html