Rural southern Ohio seems to have a deep recent history of involvement with drugs. I have been googling around and there is a bit more than speculation to suggest a Mexican cartel connection in the general area. What has been noted in this case certainly looks like small potatoes by comparison to some earlier operations with confirmed Mexican connections.
And we know that there has been a serious rural market for Oxy and other opioids, recently supplanted by heroin (possibly as a result of a state-led shut-down of rural "pill mills" several years ago).
What I don't know is how many layers exist between a Mexican operation and producers locally. I do believe in the likelihood of an ongoing tension between the folks who produce and the folks who distribute. And when there are big-money illegal operations turf is very important. Hard telling exactly what kind of violation this family committed with some piece of an operation--taking too big a cut, not paying for protection, attempting to go it alone, or just losing money via something else (like gambling on *advertiser censored*-fighting or derbies) and not being able to repay, but as Michael Corleone said, this looks to me more like business than personal.