I have to say that Dr. Wolf's description of Bipolar (off meds) is right on. I have three adult sons who have sudden onset Bipolar I, Bipolar II Rapid Cycling, and Bipolar with Mixed State. All had their onsets at age 28, not far off when it sounds as if Dr. Wolf started having problems.
I've personally witnessed every behavior (other than murder) Dr. Wolf described. It's terrifying to watch a loving, bright person turn into a monster before your very eyes. My heart breaks for his wife, Mary, as she surely knew he was on shaky ground. The mania and grandiosity wear family members out. You really get to the point of compassion fatigue. And people with bipolar desperately need their families and friends.
I know, in my heart, that Dr. Wolf must have terrible remorse. No one goes off their meds really "by choice". The euphoria and the grandiosity are horrible tricksters. They make the person feel as it they are not only well but that they are fabulous.
It's similar to when a healthy person takes a headache medication. If the headache goes away and your head feels normal (or even blissfully pain-free...in comparison to how it felt an hour ago), you are not likely to take another pill. The pain is gone.
With bipolar, when you stop your meds, mania sets in and mania feels wonderful. You can do anything, need no sleep, you feel creative and feerless, you can have sex with anyone. Food tastes better, the very air on your skin feels divine--you can fly. Why would you want to take that pill that dulls everything? That's how I've had it explained to me by my sons. I don't think any of us without bipolar or loving someone with bipolar can really understand the challenge of staying on those drugs.
The moral of this story is that we need to develop medications that can be consistently delivered...similar to an insulin pump or an implant IMO. A book that really helped me understand the importance of consistent medication is "What Goes Up: Surviving the Manic Episode of a Loved One" by Judy Eron. I can't recommend it highly enough.