But where is there any evidence of the children being given drugs. They only had calpol at most, and this is not a sedative. A sedative version was on the market for a short time, but not until after madeleine disappeared.
calpol is not the safest thing for very young children (but that has only been announced fairly recently), but there have been no cases of fatal overdose in children in the UK. It can just cause damage to the liver in the long term. No-one looking after Madeleine on the holiday noticed anything amiss with her, photos of her on the day she disappeared show her looking healthy with no signs of liver damage. It is in theory possible that she could have been fine and had a sudden overdose, but she would have needed to drink several bottles of it for it to kill her within two hours. remember she was seen alive and well and awake at six thirty, and two hours later her parents appeared at dinner, and from then until the alarm was raised they are only unaccounted for, for about five minutes each. Also for the mccanns to have time to dispose of a body on foot in an area they did not know that well, come up with the abduction idea, and ask their friends (some of whom were not good friends, and one had only met them on the holiday) to help cover up the death, it meant that Madeleine had to die in much less than two hours. I do not see how that is feasible.
Even in adults who take huge overdoses of paracetamol it is unusual for someone to just die in two hours, they normally end up getting very ill vomiting, etc. there was also no sign of vomiting or cleaning in the flat when the police turned up that night. besides, why lie? All they had to do is say Madeleine got hold of it and drank it herself (I loved calpol as a child). As I said it would not have been instantaneous, she would have become ill, why not take her to the hospital and claim she got hold of it herself? Why dump her body in a foreign country with no ceremony, and then launch an international campaign to find her drawing attention to themselves when there were much simplier lies they could have told.