Coronavirus - Global Health Emergency, 2019-nCoV #3

[margarita25]

rbbm
Single-cell RNA expression profiling of ACE2, the putative receptor of Wuhan 2019-nCov
''A novel coronavirus (2019-nCov) was identified in Wuhan, Hubei Province, China in December of 2019. This new coronavirus has resulted in thousands of cases of lethal disease in China, with additional patients being identified in a rapidly growing number internationally. 2019-nCov was reported to share the same receptor, Angiotensin-converting enzyme 2 (ACE2), with SARS-Cov. Here based on the public database and the state-of-the-art single-cell RNA-Seq technique, we analyzed the ACE2 RNA expression profile in the normal human lungs. The result indicates that the ACE2 virus receptor expression is concentrated in a small population of type II alveolar cells (AT2).

''Surprisingly, we found that this population of ACE2-expressing AT2 also highly expressed many other genes that positively regulating viral reproduction and transmission. A comparison between eight individual samples demonstrated that the Asian male one has an extremely large number of ACE2-expressing cells in the lung. This study provides a biological background for the epidemic investigation of the 2019-nCov infection disease, and could be informative for future anti-ACE2 therapeutic strategy development.''

Question,

I’ve seen and read that SARS and MERS are 80% similar to CV (moo need link).

An out of the box thought I had as I was watching a YT video of folks scrambling and racing to get fresh vegetables to China and seeing the stacks of what looked like super long green onions, I remembered some contaminations and recalls we’ve had in the US - hepatitis for green onions, e-coli, salmonella, etc. Some of these vegetable contaminations occur from cow manure contaminating the ground waters/soil, iirc, moo.

Anyway, considering the terms mentioned upstream, “fecal-oral”, “fecal swabs”, “diarrhea”, etc, I was wondering about the fecal connection.

A medical professional could probably tell me and in an instant if such an incidence could maybe be a source or not - bat droppings, maybe, things of that nature.

So I asked my friend if there is such a thinking as fecal-related respiratory syndromes, and she sent me back this:

CDC - Hantavirus Pulmonary Syndrome (HPS) - Hantavirus

I’m curious how genetically similar CV is to the above, for example.

Anyway, just wanted to throw that factor/idea out there - I wonder if their food is contaminated. Can one get this virus by eating something contaminated? Maybe not, I don’t know I’m not a medical professional.

But the fact remains, that they have not isolated the source(s). Dr. Mike referred to this in yesterday’s PC when he even mentioned the possibility of “one, two, three animals in various settings” (need to pull quote).

Anyway, my point is that there is obviously wide and initially fast transmission among those in Wuhan, and we know that person to person contact occurs, and there is a high population, etc etc so maybe the rapid spread is simply due to that. I’m just wondering about cross contamination in Wuhan specifically as related to the initial source(s). We know they’ve traced it to the market, but perhaps there are other sources like Dr. Mike mentioned, and/or maybe multiple sources within that whole market, one we may not expect. Maybe surface contamination plays a role - my point is I want to know exactly how it made the jump to humans, as many are also wondering.

That market could be contaminated from prior vendors, etc. The market is shown in various videos - They’re almost like garage booths.

—

I’m interested in learning about the “genetic sequencing”.

 

[dotr]

Operations Dashboard for ArcGIS
ETA
Numbers (confirmed CV) change rapidly.

 

[margarita25]

Operations Dashboard for ArcGIS
Coronavirus 2019-nCoV Global Cases by Johns Hopkins CSSE
Total Confirmed
34,878

Total Deaths
724

Total Recovered
2,066

(You can blink and these numbers rise. )

 

[KALI]

Oh. Damn. I'd not even thought of this. How horrible.

Coronavirus Outbreak Puts Halt To US Adoptions Of Chinese Children
Feb 6 2020
''The 3-year-old girl from China was set to be welcomed into her new home on Feb. 21, ending an arduous two-year adoption process for parents Ivy and Noah Cleveland. Then the deadly coronavirus outbreak put a sudden stop to the family’s plan to travel to China and bring Ruby home.

The Cleveland family, like many others in the US who had planned to fly to China and complete the adoption process in January and February, are now grappling with the heartbreak of not knowing how long it will be until they meet their new sons and daughters and bring them home.

“Just knowing that you have a child out in the world that you can’t get to," Ivy Cleveland, 30, told BuzzFeed News. "It’s devastating,”

Jan 28 2020
Coronavirus outbreak brings adoption process to standstill for Byron mom
While she waits across the world for her son, she can’t help but worry about the virus spreading to the orphanage.

"I feel like they're doing everything they can but of course as his mother I'm going to worry about it. He should be here with me and I should be taking care of him, but there's nothing we can do about it right now,” she said.

There’s no telling when she’ll be able to see him.

"The end was just right there and then it was just gone,” she said.

Though she’s heartbroken, she is prepared to wait as long as she needs to, in order to meet Noah and bring him home.

Lawson spoke to officials from her adoption agency Monday night. She said they told her that coronavirus has not gotten into the orphanage and that they are limiting staff and visitors to prevent the spread of the disease.''

 

[dotr]

Question,

I’ve seen and read that SARS and MERS are 80% similar to CV (moo need link).

An out of the box thought I had was as I watching a YT video of folks scrambling and racing to get fresh vegetables to China and seeing the stacks of what looked like super long green onions, I remembered some contaminations and recalls we’ve had in the US - hepatitis for green onions, etc. Some of these contaminations occur from cow manure contaminating the ground waters, iirc.

Anyway, considering the terms mentioned upstream, “fecal-oral”, and “fecal swabs”, etc, I was wondering about the fecal connection.

A medical professional could probably tell me and in an instant if such an incidence could maybe be a source - bat droppings, maybe, things of that nature.

So I asked my friend if there is such a thinking as fecal-related respiratory syndromes, and she sent me back this:

CDC - Hantavirus Pulmonary Syndrome (HPS) - Hantavirus

I’m curious how genetically similar CV is to the above, for example.

Anyway, just wanted to throw that factor/idea out there - I wonder if their food is contaminated. Can one get this virus by eating something contaminated? Maybe not, I don’t know I’m not a medical professional.

But the fact remains, that they have not isolated the source(s). Dr. Mike referred to this in yesterday’s PC when he even mentioned the possibility of “one, two, three animals in various settings” (need to pull quote).

Anyway, my point is that there is obviously wide and initially fast transmission among those in Wuhan, and we know that person to person contact occurs, and there is a high population, etc etc so maybe the rapid spread is simply due to that. I’m just wondering about cross contamination in Wuhan specifically as related to the source. We know they’ve traced it to the market, but perhaps there are other sources like Dr. Mike mentioned, and/or maybe multiple sources within that whole market. Maybe surface contamination plays a role - my point is I want to know exactly how it made the jump to humans, as many are also wondering.

That market could be contaminated from prior vendors, etc. The market is shown in various videos - They’re almost like garage booths.

—

I’m interested about learning about the “genetic sequencing”.

rbbm.
Mining coronavirus genomes for clues to the outbreak’s origins | Science | AAAS

''attaaaggtt tataccttcc caggtaacaa accaaccaac tttcgatctc ttgtagatct … ''

That string of apparent gibberish is anything but: It’s a snippet of a DNA sequence from the viral pathogen, dubbed 2019 novel coronavirus (2019-nCoV), that is overwhelming China and frightening the entire world. Scientists are publicly sharing an ever-growing number of full sequences of the virus from patients—53 at last count in the Global Initiative on Sharing All Influenza Data database. These viral genomes are being intensely studied to try to understand the origin of 2019-nCoV and how it fits on the family tree of related viruses found in bats and other species. They have also given glimpses into what this newly discovered virus physically looks like, how it’s changing, and how it might be stopped.

“One of the biggest takeaway messages [from the viral sequences] is that there was a single introduction into humans and then human-to-human spread,” says Trevor Bedford, a bioinformatics specialist at the University of Washington and Fred Hutchinson Cancer Research Center. The role of Huanan Seafood Wholesale Market in Wuhan, China, in spreading 2019-nCoV remains murky, though such sequencing, combined with sampling the market’s environment for the presence of the virus, is clarifying that it indeed had an important early role in amplifying the outbreak. The viral sequences, most researchers say, also knock down the idea the pathogen came from a virology institute in Wuhan.''

 

[gitana1]

The second video was more concerning. What a lovely couple.

That’s the one I saw when I first commented! Amazing. They’re incredible.

 

[gitana1]

rbbm.
Mining coronavirus genomes for clues to the outbreak’s origins | Science | AAAS

''attaaaggtt tataccttcc caggtaacaa accaaccaac tttcgatctc ttgtagatct … ''

That string of apparent gibberish is anything but: It’s a snippet of a DNA sequence from the viral pathogen, dubbed 2019 novel coronavirus (2019-nCoV), that is overwhelming China and frightening the entire world. Scientists are publicly sharing an ever-growing number of full sequences of the virus from patients—53 at last count in the Global Initiative on Sharing All Influenza Data database. These viral genomes are being intensely studied to try to understand the origin of 2019-nCoV and how it fits on the family tree of related viruses found in bats and other species. They have also given glimpses into what this newly discovered virus physically looks like, how it’s changing, and how it might be stopped.

“One of the biggest takeaway messages [from the viral sequences] is that there was a single introduction into humans and then human-to-human spread,” says Trevor Bedford, a bioinformatics specialist at the University of Washington and Fred Hutchinson Cancer Research Center. The role of Huanan Seafood Wholesale Market in Wuhan, China, in spreading 2019-nCoV remains murky, though such sequencing, combined with sampling the market’s environment for the presence of the virus, is clarifying that it indeed had an important early role in amplifying the outbreak. The viral sequences, most researchers say, also knock down the idea the pathogen came from a virology institute in Wuhan.''

I’m sorry to say but I have a deep disgust for the things they eat in that country. All the exotics and animals not generally considered stock in most of the world.

 

[gitana1]

Absolutely. - sadly - these facilities don’t even come close to a MASH unit. These are at best - detention camps.

Hmm where’s the nearest biohazard waste facilities/crematorium?

So do you really think he was killed? I suspect. I mean it’s too much of a coincidence if right now the risk is 2%.

 

[margarita25]

rbbm.
Mining coronavirus genomes for clues to the outbreak’s origins | Science | AAAS

''attaaaggtt tataccttcc caggtaacaa accaaccaac tttcgatctc ttgtagatct … ''

That string of apparent gibberish is anything but: It’s a snippet of a DNA sequence from the viral pathogen, dubbed 2019 novel coronavirus (2019-nCoV), that is overwhelming China and frightening the entire world. Scientists are publicly sharing an ever-growing number of full sequences of the virus from patients—53 at last count in the Global Initiative on Sharing All Influenza Data database. These viral genomes are being intensely studied to try to understand the origin of 2019-nCoV and how it fits on the family tree of related viruses found in bats and other species. They have also given glimpses into what this newly discovered virus physically looks like, how it’s changing, and how it might be stopped.

“One of the biggest takeaway messages [from the viral sequences] is that there was a single introduction into humans and then human-to-human spread,” says Trevor Bedford, a bioinformatics specialist at the University of Washington and Fred Hutchinson Cancer Research Center. The role of Huanan Seafood Wholesale Market in Wuhan, China, in spreading 2019-nCoV remains murky, though such sequencing, combined with sampling the market’s environment for the presence of the virus, is clarifying that it indeed had an important early role in amplifying the outbreak. The viral sequences, most researchers say, also knock down the idea the pathogen came from a virology institute in Wuhan.''

Thank you, @dotr for your responses.

It says the above is a “snippet” - Is the full genetic sequence available?? How can we get going on the “code”?

 

[margarita25]

I’m sorry to say but I have a deep disgust for the things they eat in that country. All the exotics and animals not generally considered stock in most of the world.

Hi Gitana1.

Yeah they were kind enough to take dog off the menu during the Beijing Olympics. Dog penis is normally on the menu, along with many other disgusting things -let’s not go there. It is freaking repulsive (and heartbreaking, especially when you get into the fur stuff, I’ve seen...). We have discussed the awful “Wet Markets” and live dog bbqs. Hopefully and thankfully this Global Crisis will bring more international awareness to these unspeakable and horrific issues.

 

[gitana1]

Please forgive me, I've not read all your posts. I have read that the virus seemed to be attacking the Asian community. Does anyone know if it's also been confirmed to be in other nationalities? I'm in no way being racist, I am wondering if this strain is more prevalent in certain ethnic groups, as sickle cell seems to be more prevalent in dark skinned people.

God no. It’s not at all the same as sickle cell anemia. One is genetic. One is communicable. Completely different.

And nationality has zero to do with ethnicity, BTW. Nationality is your citizenship. Black people and Indians and Asians and Hispanics all can have American nationality.

Geez. The virus isn’t attacking the asian community. They’re not more susceptible. People in the region where it started are susceptible and anyone who comes into contact with people who have been there, regardless of race.

You know race is pretty irrelevant mostly. Yes there are genetic issues that sometimes are more prevalent depending on ethnic background but I learned in physical anthropology that two people - one in Africa and one in the west (let’s say Europe) are likely to have more in common genetically with one another than two people of African descent. Because there’s such genetic diversity in Africa.

After all, we share about 96% of our genetics with chimps. So logically the genetic differences between humans of different ethnicities is negligible. “Race” doesn’t really exist. (And nationality is political, not genetic).

 

[gitana1]

My friend and her wife were planning on adopting a baby girl from China. I wonder how that’s going to work out now.

Probably okay. Maybe a delay. If they have been matched the baby will be tested and they will probably have to wait to go over.

 

[gitana1]

Ugh, yes, I'm terrified of the flu. I get rapid drops in electrolytes and become frighteningly weak. My breathing slows. It truly terrifies me how to handle any serious illness since this started for me. I read about one man's experience with the CV and he talked about being so weak for days he could only eat because his sister would lift his head and hold the straw for him. He said other people who were elderly basically got no help because no one was with them to help him. It was the experience of weakness he talked about that really got me. It's a huge anxiety trigger for me...

I hear ya. My asthma makes me realize I’m unlikely to survive a serious virus, the older I get. It’s scary.

 

[dotr]

rbbm.
''2019 Novel Coronavirus (2019-nCoV) Situation Summary
This is an emerging, rapidly evolving situation and CDC will provide updated information as it becomes available, in addition to updated guidance.''

Updated February 7, 2020

2019 Novel Coronavirus (2019-nCoV) Situation Summary | CDC
''Source and Spread of the Virus
Chinese health authorities were the first to post the full genome of the 2019-nCoV in GenBankexternal icon, the NIH genetic sequence database, and in the Global Initiative on Sharing All Influenza Data (GISAIDexternal icon) portal, an action which has facilitated detection of this virus. CDC is posting the full genome of the 2019-nCoV viruses detected in U.S. patients to GenBank as sequencing is completed.

2019-nCoV is a betacoronavirus, like MERS and SARs, both of which have their origins in bats. The sequences from U.S. patients are similar to the one that China initially posted, suggesting a likely single, recent emergence of this virus from an animal reservoir.

Early on, many of the patients in the outbreak of respiratory illness caused by 2019-nCoV in Wuhan, China had some link to a large seafood and live animal market, suggesting animal-to-person spread. Later, a growing number of patients reportedly did not have exposure to animal markets, indicating person-to-person spread.''

 

[dotr]

Thank you, @dotr for your responses.

It says the above is a “snippet” - Is the full genetic sequence available?? How can we get going on the “code”?

Dunno, it is all Chinese to me!
rbbm.
Experts monitoring coronavirus for signs of tipping point in coming weeks
''The virus is currently fatal in 2 per cent of reported cases, although many experts suggest that percentage is likely to decline as more milder or asymptomatic cases come to light.

However, the total number of cases emerging at this point has experts puzzled, because it doesn’t fit with accounts that the virus emerged in mid-December, starting with a cluster of cases linked to a live animal market in the city of Wuhan.

To illustrate this, David Fisman, an epidemiologist at the University of Toronto’s Dalla Lana School of Public Health, created a model with minimal assumptions to try to fit the reported number of cases to what is known about the dynamics of an epidemic.

His results, published Wednesday in the Annals of Internal Medicine, strongly suggest the virus was more likely circulating in the human population of Wuhan as early as mid-November. This squares with other studies that argue there had to be more cases of the virus at an earlier time to match the current profile of the emerging outbreak.''

 

[margarita25]

Quote from dixiegirl1035 from the last thread:

“As an aside, I sat in silence and paused the feed when transcribing this am and considered today the WHO head today in the presser said that "the folks in Wuhan were suffering and giving for humanity in this crisis".

What a striking recognition and statement.”

I’m tellin ya, Dr. Tedros is da bomb (so are Dr. Mike and Dr. Maria) moo. I can feel Dr. T’s heart is of huge compassion, and as I said earlier, his few words say so much, AND he’s obviously brilliant to be the WHO Director General.

I’m curious from which nation he is. Do we have his bio yet?

ETA: C’mon @dotr, you’re slackin’... I need that GENETIC SEQUENCE AND BIO NOW!!!
Seriously, thank you for the tag team support, I’m trying to keep up, almost done with thread 2. You and @dixiegirl1035 have some long posts lol.

 

[gregjrichards]

I’m sorry to say but I have a deep disgust for the things they eat in that country. All the exotics and animals not generally considered stock in most of the world.

I sincerely hope new laws will be brought in by the Chinese government about what can be eaten to prevent future outbreaks with these disgusting markets banned. Surely people in China will be more concerned now about what they can eat for fear of catching the virus.

 

[gregjrichards]

New York Times is reporting an American in Wuhan has died of the virus. I wish I had a subscription to post a link.

 

[margarita25]

Quote JerseyGirl from the last thread:

“China's Ambassador to the U.K. has continued the Chinese government's criticism of some Western nations' response to the deadly coronavirus outbreak. Ambassador Liu Xiaoming told journalists in London Thursday that British leaders' "words do not match with (their) deeds," pointing to the U.K. government's advice to citizens to leave China as soon as possible.

Liu said there had been an "overreaction by individual countries." China has also balked at U.S. warnings against all travel to the country.

The ambassador stressed that the head of the WHO, Dr. Tedros Gebreyesus, on Wednesday said that adopting a "blanket approach" — banning travel to and from all of China or urging people to leave the vast country when 80% of the confirmed cases of the illness were still in just one province, could prove unhelpful.

"It's hoped that governments of all countries, including U.K., should understand and support China's efforts, respect the professional advice of the WHO, avoid overreaction and creating panic and ensure normal cooperation and exchanges between countries."

Liu stressed that, "not the whole of China is an outbreak area. Life is still normal in most parts of China."

Coronavirus deaths mount as U.S. plans more evacuations from outbreak epicenter in China

yeah, right. :eyeroll: “

Double eye roll.

 

[gregjrichards]

My life in 'Camp Corona': Teacher who was stranded in Wuhan amid the coronavirus outbreak tells of the reality of life in quarantine after being evacuated to the UK

My life in 'Camp Corona': Teacher who was stranded in Wuhan tells of reality of life in quarantine | Daily Mail Online

I wish the people quarantined in China were being as well looked after.