Multisystem inflammatory syndrome in children (MIS-C and COVID-19)

[margarita25]

17 May, 2020

[...]

“Methods: Over a two-month period contemporary with the SARS-CoV-2 pandemic in France and Switzerland, we retrospectively collected clinical, biological, therapeutic, and early outcomes data in children who were admitted to pediatric intensive care units in 14 centers for cardiogenic shock, left ventricular dysfunction and severe inflammatory state.”

[...]

“Conclusion: Children may experience an acute cardiac decompensation due to severe inflammatory state following SARS-CoV-2 infection (multisystem inflammatory syndrome in children - MIS-C). Treatment with immune globulin appears to be associated with recovery of left ventricular systolic function.”

More at link:
Acute heart failure in multisystem inflammatory syndrome in children (MIS-C) in the context of global SARS-CoV-2 pandemic
17 May 2020

 

[JerseyGirl]

Two South Carolina children diagnosed with MIS-C: health condition linked to COVID-19, DHEC says

“The Department of Health and Environmental Control says both children are under the age of 10. One is from the Midlands region, and one is from the PeeDee region.

“We continue to see more and more young people, especially those under 20, contracting and spreading COVID-19, and we know MIS-C is a threat to our youngest South Carolinians,” said Dr. Linda Bell, State Epidemiologist. “MIS-C is a serious health complication linked to COVID-19 and is all the more reason why we must stop the spread of this virus. Anyone and everyone is susceptible to COVID-19 as well as additional health risks associated with it, which is why all of us must stop the virus by wearing a mask and stay six feet away from others. These simple actions are how we protect ourselves and others, including our children.”

The first reports of this syndrome came from the United Kingdom in late April. Cases in the United States were first reported in New York City in early May.“

First cases of coronavirus-related inflammatory syndrome identified in children in South Carolina

 

[margarita25]

This article doesn’t mention MIS-C specifically, but wanted to note for reference re: 6 month old baby:

Texas city lists newborn's death as COVID-19-related

““I want people to know that even if you have no symptoms like baby Isaiah did, you could still have the virus," Jacqueline Cruz told the station. "He tested positive and had a fever but was released because the fever had subsided."

Cruz said her sister, Isaiah’s mom, took him to the hospital because he had a rash and a "little bit of a fever," the station reported.

After being tested for the flu and COVID-19, his results were positive for the coronavirus, according to the station.”

[...]

“"Isaiah was a very happy baby," she told the station. "There's tons of pictures on my sister's Facebook with him smiling. She took a video of him hours before he passed away. He was smiling -- he was in the car seat, she was playing with him. He was smiling away."

Corpus Christi Public Health District Director Annette Rodriguez told reporters Friday the baby had other health issues, according to the station.

The station also reported that the baby’s death is being classified as a SIDS -- sudden infant death syndrome -- fatality, but is considered a COVID-19-related death because he was ill with the virus.“

 

[JerseyGirl]

COVID-19 related MIS-C in kids can spark a treatable type of heart failure

Researchers have described the warning signs – and management approaches taken - in 35 French children who ended up in ICUs with a SARS-CoV-2 related fever, severe multisystem inflammation, left-ventricular dysfunction and cardiogenic shock.

“It is an emerging rare but serious problem linked to the coronavirus pandemic in children,” said Dr. Damien Bonnet, a professor of congenital and pediatric cardiology and head of the French National Reference Center for Rare Cardiac Disease in Children at the Necker-Infants Malades Hospital at the University of Paris. “Being aware and knowing the presenting symptoms allow one to treat early and efficiently.”

 

[JerseyGirl]

Baby boy infected with coronavirus in womb

Doctors in France have reported what they believe to be the first proven case of Covid-19 being passed on from a pregnant woman to her baby in the womb.

The newborn boy developed inflammation in the brain within days of being born, a condition brought on after the virus crossed the placenta and established an infection prior to birth. He has since made a good recovery.

The case study, published in Nature Communications, follows the birth of a number of babies with Covid-19 who doctors suspect contracted the virus in the womb. Until now, they have not been able to rule out the possibility that the babies were infected during or soon after delivery.

 

[margarita25]

At least 31 percent of children tested in Florida are positive for COVID-19: report

“Meanwhile, the CDC issued an advisory back in May regarding a severe inflammatory condition found in children believed to be associated with the coronavirus. Doctors describe the inflammatory condition (MIS-C) as similar to Kawasaki disease, a rare illness that causes swelling in medium-sized arteries throughout the body.

The pediatric report lists 13 such cases in Florida in children under the age of 18.”

 

[margarita25]

(Post courtesy of @SouthAussie from Covid-19 discussion thread)

July 17, 2020 - 03:54 GMT - US counts 342 child inflammatory syndrome cases

An official with the US Centers for Disease Control and Prevention has said the most recent count shows 342 US children and teens have developed a serious inflammatory condition linked to COVID-19 infections.

Dr Ermias Belay told physicians that among the US cases reported as of July 15, the average age was eight and most children were aged between one and 14.

WHO reports record global daily coronavirus cases increase: Live

 

[margarita25]

This article doesn’t specifically mention MIS-C, but marking for reference:

85 children under age 2 tested positive for coronavirus in 1 Texas county, as U.S. sets new record

 

[margarita25]

“Early data from the U.S. Centers for Disease Control and Prevention published in the spring found that infants made up less than 1% of cases nationally.

Although children are believed to be at a lower risk for the virus, infants "may be at higher risk for severe illness," the U.S. Centers for Disease Control and Prevention warns.“

COVID-19: Florida counties impose curfews as cases surge in state

 

[ArianeEmory]

Most young virus cases in Texas county diagnosed this month

 

[margarita25]

Minnesota reports child COVID-19 death, more than 900 new cases

“The death of a 9-month-old baby from Clay County is one of the youngest reported in the U.S. in the pandemic.

The child had no underlying health conditions and was not hospitalized. State Health Commissioner Jan Malcolm described it as an "isolated incident related to this infant's very specific situation."“

[...]

“"An infant death is devastating," said Kris Ehresmann, state infectious disease director, "and thankfully there have not been a lot of infant deaths in the country, but we want to make sure that we're understanding as much as we can about ... the changes that occurred with this infant in terms of the progression of their illness."“

[...]

“Even so, health officials have warned that COVID-19 can pose risks to younger people, including breathing and other health complications. The state has reported pediatric cases of COVID-19 that required hospital admissions and intensive care, as well as at least 13 cases of multisystem inflammatory syndrome in children. The condition affects multiple organs and appears tied to earlier SARS-CoV-2 infections.“

[...]

“Cases among children and young adults have fueled the increase in the outbreak in the state over the past month. Total cases in Minnesota have increased 87% since June 1, but 144% among people 29 and younger in that same time period.“

 

[margarita25]

Coronavirus ‘cluster’ grows at southeast Charlotte daycare, 7 children test positive

“North Carolina says that another child has tested positive for COVID-19 at a southeast Charlotte daycare.

That currently makes two clusters at daycares in Mecklenburg County.

State health officials say that seven children have been infected with the coronavirus at Kindercare Providence at 1700 Providence Road.

Health officials consider a cluster a group of five or more cases.”

“In recent weeks, both Atrium Health and Novant Health have reported more children testing positive for COVID-19. Levine Children’s Hospital Epidemiologist Dr. Amina Ahmed says that is in part because more children are being tested now than they were at the beginning of the pandemic.

“Again, the vast majority off kids will have mild disease—we know that nationally, globally, etc. But we are going to have some kids that have this MIS-C,” Dr. Ahmed said.“

 

[margarita25]

This article does not mention MIS-C, but posting here because it refers to babies:

North Texas Counties Report at Least 433 Babies Test Positive for COVID-19 Since March
Number of COVID cases in babies under-reported across Texas

“NBC 5 found more than 430 babies have tested positive for the virus in the four largest counties in North Texas even though the Texas Department of State Health Services is currently only reporting 125 cases in children ages 1 and younger.”

[...]

“These cases haven’t been reported to the state but doctors say these are numbers that give a glimpse into how widespread the virus really is.

Over the weekend, Nueces County Health Department, made headlines after they reported that 85 infants had tested positive for coronavirus since March. It’s the same county where a 6-week-old baby from Corpus Christi died in June.

“We have community spread, I think people should assume there is community spread wherever they are at this point,” said Dr. Angela Moemeka, a pediatrician at MARK 9 Pediatrics.“

 

[margarita25]

Clinical Management of Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with Coronavirus Disease (COVID-19)
Clinician Outreach and Communication Activity (COCA) Webinar
July 16
CDC / Slides

 

[margarita25]

Article on MIS-C

Cases of rare condition in kids caused by COVID-19 reported in Arizona

““It is very rare, but we are seeing it,” said Dr. Josh Koch, division director of the pediatric intensive care unit at Phoenix Children’s Hospital. “It seems to occur somewhere between 3 to 6 weeks after COVID infection.”“

[...]

““The most dangerous thing about it is its effect on the heart and cardiovascular system,” he said. “Many of these patients have decreased function of their heart. They have lower blood pressures and they’re very, very inflamed.”

He said some of the outward signs that appear in children with this disease include red eyes and rashes.

“That’s basically the inflammation we can see on the outside of the body,” Koch explained. “That same inflammation is occurring on the inside of the body on the internal organs, and the organ that it seems to affect the most from a dangerous standpoint is the heart.”

[...]

“In addition to Phoenix Children’s Hospital, Banner Health hospitals in the Phoenix and Tucson areas have also reported cases of MIS-C.“

Cases of rare condition in kids caused by COVID-19 reported in Arizona

 

[margarita25]

MIS-C not mentioned, but marking for reference:

“On Monday, health officials reported a 9-month-old infant from Clay County had died of COVID-19--the youngest person to die from the disease in the state to date.”

[...]

“MDH epidemiologist Kris Ehresmann said the infant had symptoms with what you might expect from COVID-19, including respiratory symptoms and evidence of some inflammation in the upper airways, but they were never hospitalized.

The infant did not have any underlying health conditions, she said.

Ehresmann said they have sent specimens from the infant to the Centers for Disease Control and Prevention, which will will do additional evaluation of the case.

“We want to make sure that we’re understanding as much as we can about the physiologic changes that occurred with this infant in terms of the progression of their illness as well as we want to make sure any information that’s available on the course of this infant’s illness is added to the broader understanding of infant deaths around the country," Ehresman said.”

COVID-19 in Minnesota: State reports 507 new cases, 4 more deaths

 

[margarita25]

2 Colorado children die of coronavirus-linked inflammatory condition

“At least two youths in Colorado have died after developing a rare coronavirus-linked inflammatory condition known as Multisystem Inflammatory Syndrome in Children (MIS-C), health officials in the state said this week.

A total of seven children in the state have developed the syndrome, a spokesperson for the Colorado Department of Public Health and Environment (CDPHE) confirmed to Fox News on Friday. The cases have also been confirmed by the Centers for Disease Control and Prevention (CDC).“

[...]

“These findings suggest that a substantial proportion of the patients in this series were infected with SARS-CoV-2 at least 1 to 2 weeks before the onset of MIS-C,” the study’s authors wrote.”

 

[margarita25]

Neonatal Cluster / Australia / MIS-C not mentioned but noted for reference / (Link courtesy of @tmar)

“A baby at the Royal Children's Hospital aged under three weeks has tested positive to coronavirus as four cases have emerged in a cluster at the Neonatal Intensive Care Unit (NICU).“

[...]

“More than 200 children under four have contracted COVID-19 in Victoria.“

Melbourne baby in hospital ICU with COVID-19

 

[margarita25]

MIS-C not mentioned / noting for reference:

9-year-old girl becomes youngest person in Florida to die of COVID-19

“Family members said the girl did not have any underlying health conditions when she came down with a raging fever.

She was doing good at one point, and all of a sudden she had a situation with a fever,” Cain said.

BBM:
The girl’s mother took her to the hospital for treatment, but she was sent home, relatives said. She collapsed a short time later and died after her heart failed.”

 

[margarita25]

SC announces new case of MIS-C along with 1,346 new COVID-19 cases, 45 more deaths

"DHEC also announced another child in South Carolina has been diagnosed with Multisystem Inflammatory Syndrome in Children (MIS-C), which is associated with COVID-19. The child is between the ages of 10 and 17 and lives in the Upstate, where three other recent MIS-C cases have also been identified."