I just mentioned the McCann case yesterday on the search thread because it really is quite similar.
The parents left three-year-old Madeleine and her two younger twin siblings (yes, younger - just toddlers) alone in their suite while they went around the corner and across a courtyard to a tapas bar some distance away. Child care was available but they chose to do the 'checking' system of parents going around from time to time to look in on the kids. That would never fly as a defense in the U.S., but that is not considered "neglect" in Portugal.
At some point that night Madeleine "disappeared." A window screen was ajar - a second-story window.
The parents acted strange, even going running as usual the next day, and they did not help much with the searching. Much later, a cadaver dog hit on their car, which they said had been used to haul garbage to a dump including chicken bones. Later, there was also a hit from a cadaver dog near a couch where the child might have climbed up and fallen out the window, or where the body might have been hidden.
People suspected a cover-up as some of the friends of the family said they had seen odd suspects walking around carrying children (nothing was ever proven) and as sightings rolled in from around the world (all of them mistaken identities).
Very similar situation, except these people in Missouri were drinking boxed wine, not fine wine at a Portugal resort. :twocents: Like the Missouri mother, they wanted "grown-up time", only the people involved were attractive doctors with high-profile friends (J.K. Rowling has apparently helped the family financially).
And somebody is probably going to jail for something here in the U.S., while the McCanns are off living their lives in Scotland.