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An example of a gradual depressurization is the golfer Payne Stewart's plane crash. They all passed out and just flew until their plane crashed.
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http://www.cnn.com/US/9911/23/stewart.crash.03/
Sounds like they didn't pressurise the A/C from their initial checklist. Once you ascend over 10 thousand feet, you can suffer from hypoxia. At 18 thousand feet you have a UTC useable time of consciousness of 20-30 minutes, 25 thousand feet 3 to 5 minutes. The F/D would have received a Master Caution Warning, depending on the type of A/C. View Helios Airways Flight 522. Sounds like Pilot error.