MojaveMave
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It is what it is - but for some people, it can be something like sniffing glue
<<These reports indicate that brief exposure to large amounts of coal tar creosote may result in a rash or severe irritation of the skin, chemical burns of the surfaces of the eye, convulsions and mental confusion, kidney or liver problems, unconsciousness, or even death.>>
ATSDR - Public Health Statement: Creosote.
That applies mostly to burning products made with creosote resins, not necessarily the wild bushes themselves. But we were always told not to breath in the fumes/smoke when the bushes were burning. In a standard household fireplace, the danger would likely be more of the resin coating the chimney than fumes causing problems. Ranchers commonly like to burn them to get rid of them.