Locally on Dayton TV they said that Naloxone works but you START at five times the dose for Heroin and go up from there...
RE: Narcan
NO LINK.
JUST MY OPINION from working in ER
If someone OD's on a drug that is time released or extended release it keeps re-releasing over a certain period of time so it maintains certain level in blood and available for the opiate receptors in body.
Examples of are some ORAL meds are:
MS Contin (long-acting Morphine)
Oxycontin (long acting oxycodone)
The way a time-released pill is coated/formulated allows it to keep releasing over a period approx 12 hours. The entire dose is not released all at once. (that's why warnings say don't crush or chew them-- you'll get way too much all at once).
When ONE dose of Narcan is given it works for most part on short acting drugs.
BUT a long-acting or sustained-release drug releases once, then again and then again much later on. Each time it releases again more becomes available in the boodstream for our opiate-receptors to grab onto. So a pt can AGAIN become oversedated, can stop breathing, etc in a cyclical manner. So ADDITIONAL doses of Narcan may be needed until the entire drug clears system.
Topical Fentanyl patch is designed lasts 72 hours (give or take). When pt OD's with extra patches, it gets really tricky and must observe or constantly. Sometimes more Narcan doses may be needed over long time period.
Seems heroin is being mixed w analogue of Fentanyl so maybe that's why it's happening. The time release factor possibly?
Way O/T but I hope I worded it in a way that makes sense.