A few more details from the Spanish press. Apologies for any repetition:
*Joaquín Amills, president of CNDES (National Centre for the Disappeared - connected to the Ministry of the Interior), is acting as the family's spokesperson. He has gone on record as saying he is extremely concerned and that, in his experience, this type of situation rarely has a good outcome.
*He also made the point that, despite being widely shared, he's surprised that so far, not a single piece of information has been lodged with the Centre. Basically, no calls, no clues.
*Ana's doctor prescribed her anti-depressants following the divorce. The divorce is described as "complex."
*The press here says the gap between the English text and the Spanish text was of 3 hours, not 2. And to be clear, both texts were to her friends, not the brother. I'm assuming Sanna forwarded on her text to him.
*The day after her disappearance, the fire department were called and they accessed her flat via a window. They found nothing out of place, nothing supposedly missing. (Except for her phone). On the 4th, one of her friends (Sanna, I assume) officially denounced her disappearance with the National Police. (Denouncing someone or something is basically giving a statement to the police in Spain, after which the complaint is then transferred to the appropriate department -- this can be anything from a noisy neighbour to a missing friend).
*Amills said that from the very beginning, it has been "difficult to imagine" that her disappearance was voluntary. So, we can be almost certain that the police didn't waste any time in seeing suspicious elements in this case.
*My own observation: there is heavy use of CCTV across Madrid, but particularly Salamanca. This is double-edged. On the one hand, it's a tremendous amount of footage to sift through. On the other, the likelihood of someone leaving the area with Ana and being seen by no eye or lens is extremely hard to imagine. Even if an intruder had a car waiting nearby, the police would be able to trace such a movement from the car, to her building, and back out again.
*According to CNDES, Ana is 1'45 metres tall and weighs 45kg. So, very petite.
If Ana was going away voluntarily with someone for a couple of days, wouldn't she pack a bag, so there would be a suitcase or something missing from her apartment? If she left her apartment in a hurry to go off with this person, wouldn't the room be somewhat in disarray if she grabbed a few items of clothing and left quickly?
As for the cameras around her apartment building, if she disappeared from some other location then she wouldn't appear on the cameras near her residence.
Perhaps they are also looking at CCTV from near her therapist's office if she went there the day she went missing.