Some animals (and some people) won't/can't take pills. Rather than giving injections, which could cause a lot of discomfort if they needed it every day, so people choose to mix a liquid into a food or drink. :twocents:
Does ami have an enteric coating?
I was invited to stop by and I'm picking my way seeing where I can answer a question or two. You are so right about the medical complexity. An internist I think is quite brilliant set out to answer it all in simple terms for me and fifteen minutes later was saying, wow this gets very complex in a hurry! Kudos to anyone that can figure it out correctly. Even our experts don't completely agree but there is a complete consensus the the Amitriptyline is what killed her and it was a very large, one time dose.
This will teach me to actually go to sleep. Now I have 10 pages to process of some amazing information. Good discussion everybody.
I'm glad to see morgansfather on here.
I'm finding all this drug talk fascinating, loving the experts here bouncing ideas and questions off each other.
I have a question about the 'cumulative effect' - the only drug familiar to me that I knew was cumulative before now was acetominophen (paracetamol in the UK, Tylenol here). I always understood, wrongly I guess, that it built up over time in the organs - ie stayed in the body forever - which is why it is dangerous to take it continuously for long periods of time even if you stay within the 'safe' daily dosage. Reading here I'm realising that 'cumulative' probably doesn't mean what I've always thought it means and to discover also that one drug can metabolize into another drug altogether that's mind-boggling!
Google is NOT being my friend in this instance since all I'm getting is pages and pages of words I can't even pronounce let alone understand or a very bald definition which doesn't really explain much:
"Cumulative effect: the state at which repeated administration of a drug may produce effects that are more pronounced than those produced by the first."
So I'm thinking the answer to the question I was going to ask: would the prescribed ami Morgan had been taking 2 years earlier have built up in her system and contributed to the high readings - is 'no'.
But that definition raises another question though - if Morgan had taken some ami during the stalking period would succeeding doses or, more specifically, one sudden higher dose take effect quicker than normal and produce a more pronounced reaction to it?
Thanks in advance to anyone who can make sense of and answer my question.
It would have been out of her system long before that. When you start taking an antidepressent and many other drugs, it can take weeks for them to get up to a theraputic level in your system. That's basically because the dose you take is slightly higher than the amount your body metabolizes. Once you stop taking them, it can sometimes take weeks for all traces to be out of your system, but unless there is a physical problem that keeps your body metabalizing it, it will eventually be gone.
What I was told about the second question is that with many drugs you can build up a tolerance to them, just like with alcohol, and it will take more to achieve the same effect. With some it's possible that even after you stop using them, you keep the tolerance (or at least for a fairly long time) and it actually takes more to reach the same point. I have no idea if it's true with amitriptyline, but if it is, it would actually take longer rather than be quicker. Sorry I can't give more definite answers, but it was explained to me many years ago and it isn't the same drug that was being discussed.
As always, my opinions sprinkled with my typos.
It might have...but it would be hard to mask that taste. Not that I've tasted it, but from what I've read today, that stuff is about as bad as anything you've ever tasted...not like "ew, tastes bad but I can get it down", rather more like the body takes over and decides to get rid of it through vomiting kind of taste.
Best-
Herding Cats
What if it was compounded? I found a company that flavors these drugs for animals with fruit flavors.
The other thing I was thinking of...a large veterinary practice would have their own in-house pharmacy. The doses for dogs and cats may be small, but they would likely have to be dispensed into the take-home size from a larger bottle. It's possible the pharmacy has the drug at a higher concentration which is mixed with water to provide to the patients.
Why bother going through all of that? Elavil can be more commonly found circulating amongst humans; ex. High Schools, Colleges, etc
Point is this, it is not a drug that is commonly found at horse ranches.