margarita25
Well-Known Member
- Joined
- Oct 10, 2012
- Messages
- 51,429
- Reaction score
- 207,290
April 20 / source:
“Gabriela: (36:33)
Hi. Thank you very much for taking my question. I read about a study suggesting that rather than the virus weakening the lungs as had been thought, growing evidence shows that the virus is actually, it’s stripping red blood cells of its oxygen, giving the appearance of long [inaudible 00:36:52] and forcing the lungs to work harder. So without oxygen, the body is effectively being starved of energy and dying. So what are your comments on this? Did you heard about this? Thank you very much.
Dr. Michael J. Ryan: (37:08)
Yeah, I believe it’s likely that both processes are occurring. There’s certainly no question that there’s a direct impact on lung tissue from the virus itself. But there is this observation of rapid desaturation or rapid loss of oxygen in the blood and we’ve seen many, many reports of this. And clearly there are multiple physiologic or pathological pathways in action here. It’s not just the lungs are affected, many other organs are affected. And I think it’s a dynamic issue. There’s also the direct effect of the virus and then there’s the immune response to the virus. And in effect, we may be seeing in some cases a very robust immune response. Sometimes the immune system overreacting. And we’ve seen this in many other emerging diseases as well. So we may see a mixture of the immuno modulated responses.
In other words, responses to the virus that are modulated by the immune system that may help kill the virus, but they may also do tissue damage. We see the direct effect of the virus itself. And then we see the effect on the oxygen carrying system, which begins in the lungs, continues in the red blood cells and goes all the way to the tissues. And at this point I believe clinicians around the world and pathophysiologists are really looking at what is the contribution of each of these potential pathways to the overall morbidity and overall mortality of this disease.”
“Gabriela: (36:33)
Hi. Thank you very much for taking my question. I read about a study suggesting that rather than the virus weakening the lungs as had been thought, growing evidence shows that the virus is actually, it’s stripping red blood cells of its oxygen, giving the appearance of long [inaudible 00:36:52] and forcing the lungs to work harder. So without oxygen, the body is effectively being starved of energy and dying. So what are your comments on this? Did you heard about this? Thank you very much.
Dr. Michael J. Ryan: (37:08)
Yeah, I believe it’s likely that both processes are occurring. There’s certainly no question that there’s a direct impact on lung tissue from the virus itself. But there is this observation of rapid desaturation or rapid loss of oxygen in the blood and we’ve seen many, many reports of this. And clearly there are multiple physiologic or pathological pathways in action here. It’s not just the lungs are affected, many other organs are affected. And I think it’s a dynamic issue. There’s also the direct effect of the virus and then there’s the immune response to the virus. And in effect, we may be seeing in some cases a very robust immune response. Sometimes the immune system overreacting. And we’ve seen this in many other emerging diseases as well. So we may see a mixture of the immuno modulated responses.
In other words, responses to the virus that are modulated by the immune system that may help kill the virus, but they may also do tissue damage. We see the direct effect of the virus itself. And then we see the effect on the oxygen carrying system, which begins in the lungs, continues in the red blood cells and goes all the way to the tissues. And at this point I believe clinicians around the world and pathophysiologists are really looking at what is the contribution of each of these potential pathways to the overall morbidity and overall mortality of this disease.”