Ummm, I'm not sure if I would call her husband in the middle of the night, If I wasn't sure that maybe she hadn't slipped out to meet up with someone I didn't know about....I don't know, it depends upon the total circumstances, I guess.
That's my point, though. The waiting to contact him for several hours, either on the part of her friend or on the part of LE. I'm not suggesting it's indicative of something sinister on the part of her friend or her husband or anyone involved, just that there would have to be some reason to wait that long to contact him.