I just want to add my two cents worth and Kimster, I hope I am within the perimeters that are set here.
Although I do think drugs play a part, I'm not sure if its in the way we are assuming. Misty's Grandma says she thinks Haleigh was sexually assaulted, she is asked why she thinks that and her answer is she just thinks so because Misty heard Haleigh crying in the next room. Before we learned this our astros had said that sexual interest in Haleigh played a part (refer to Astrology thread). If this is true then it would seem that Haleigh was alive when Joe and Tommy were at her home, thus lending credibility to Grandma Hollar's story. If Haleigh was dead if and when Misty called for help to dispose of her I can't see anyone raping her. So my conclusion is that the drugs are to be included by those using them, Misty, Joe, Tommy, Ron or by whomever else was there.
(This is so horrific to even type, I can't imagine being in the presence of men raping a five year old and doing nothing to stop them)
And yet, Grandma Sykes doesn't show emotion.
I am inclined to think there is another serious crime of immense proportions that Ron is involved in but not in Haleigh's death outright. His association with this caliber of people assured the death of his child and just by the grace of God Butterbean was spared.
I also noted during this interview that Grandma Hollar seemed perched to defend her remarks against anyone. She had a glint in her eye.
These are just my opinions.