Reasons why this case is sketchy and is probably going to get busted wide open quickly:
The husband doesn't ever mention calling her when he didn't find her in the house. Did he try her friends? Maybe she had a coworker pick her up for drinks..
The lockbox is gone. Obviously perp isn't versed on how they work and got prints all over them, subsequently creating the need to destroy the box (or cut it off in some way).
Husband got texts from her at 1am after she was reported missing with inaccurate statements (going to have drinks)..did he call the phone at that time? Did he immediately call the police to tell them that he got communication from her phone? From the police report, they began searching and securing the scene around 0047...so he got these texts from her at or around 1am and the police weren't told? If they were told, maybe they could've tried for a ping at that moment since the phone was being used. Why would a perp be so dumb as to text from an iPhone, knowing the tracking capabilities and the chance of texting inaccurate info? They wouldn't. They'd throw that phone as far as possible and as soon as possible. No one keeps evidence like that when they abduct someone. There have been cases of husbands being perps and sending "inaccurate" texts like this to solidify the idea that "oh she MUST be kidnapped, bc she doesn't drink."
He has access to her phone records...look and see who she talked to. Since her phone and iPad are synced, look for her location...Find My iPhone.
Family requesting blood hounds right out the gate, and husband hiring a helicopter...why be so sure she's dead?
The husband is very talkative about the details according to him, and seems to be making things up as he goes. Watch his interview again and notice these things.
Recent weight loss and improvements to her appearance (tanning and all that)...maybe she was seeing someone on the side, someone new, and husband found out.