I knew of someone who committed suicide after 2 weeks of an antidepressant change. Apparently, she had been on them for awhile and then they stopped working for her, so it was changed. No one in her inner circle, but family, had a clue she was having problems, and it wasn't until after she was pretty much not seen for 2 weeks due to "being really sick" that her friends finally took notice. She killed herself with her whole family, including children, in the house. It was described to me that antidepressants, specifically in the young, but also after a drug change, that suicidal thoughts can manifest and the antidepressant gives them the energy to act own it. IMO, and info can be found in google.
One thing that puzzles me is the 1st ME saying she had been taking Ami for 8-9 yrs. This report is his re-classified report, so did he not take notice of the amount of metabolite in relation to the amount of Ami, as described by the consulting ME? So, bare with me as I can't do the math, is the amount of metabolite consistent with what it would have been if she had been taking her regular dose daily? If she died within 30 min, is the rate the Ami was metabolized consistent with that 1 time overdose of 8 25mg? Is it possible to metabolize Ami to the amount of the metabolite found within 30 minutes? Or could that metabolite have already been present from previous much smaller doses, and the metabolite from the larger dose just wasn't metabolized completely yet?
I'm not trying to support or debunk any theory. I'm truly curious by the disparity between the 2 ME's reports on this issue.
I'm also curious by the qty her script was for and how many were missing. I've actually filled scripts before and then decided after the fact to not take the drug. That bottle found could very well have been a full bottle, expired, left in the cabinet, and then she started taking it. I'm not suggesting she used this script to OD on, she very well could have gotten ahold of the orange 75mg ( or maybe murdered?) We may never know, of course, but I'm just curious if she could have started taking the Ami again by using her old remaining bottles of the script. These are just my thoughts.
Eta: when I say the consulting ME - Dr Doberson, I'm referring to his findings in regards to the original Tox report.
One thing that puzzles me is the 1st ME saying she had been taking Ami for 8-9 yrs. This report is his re-classified report, so did he not take notice of the amount of metabolite in relation to the amount of Ami, as described by the consulting ME? So, bare with me as I can't do the math, is the amount of metabolite consistent with what it would have been if she had been taking her regular dose daily? If she died within 30 min, is the rate the Ami was metabolized consistent with that 1 time overdose of 8 25mg? Is it possible to metabolize Ami to the amount of the metabolite found within 30 minutes? Or could that metabolite have already been present from previous much smaller doses, and the metabolite from the larger dose just wasn't metabolized completely yet?
I'm not trying to support or debunk any theory. I'm truly curious by the disparity between the 2 ME's reports on this issue.
I'm also curious by the qty her script was for and how many were missing. I've actually filled scripts before and then decided after the fact to not take the drug. That bottle found could very well have been a full bottle, expired, left in the cabinet, and then she started taking it. I'm not suggesting she used this script to OD on, she very well could have gotten ahold of the orange 75mg ( or maybe murdered?) We may never know, of course, but I'm just curious if she could have started taking the Ami again by using her old remaining bottles of the script. These are just my thoughts.
Eta: when I say the consulting ME - Dr Doberson, I'm referring to his findings in regards to the original Tox report.