Exactly! He agrees that ACE inhibitors are not good. That is why it took me 2 times to understand, and now I am going through again to take notes to drill into my mind as It is EXTREMELY confusing. Once you asked me, I'm rewinding and rewinding to try to get out of my head to you as I'm not good at ALL in communicating.
Try this.
View this chart from the video at about 7:30 into explaining. The RIGHT side of the cascade is shut down due to the virus landing on and filling the normal cascade of the ACE2 enzyme..they can no longer help which is the normal path for balance with an option for pulmonary arteries to vasodialate and have anti-fibrotic tendencies. These ACE2 are only on the "type 2 aveolar cells". Ok.. with me so far?
View attachment 243880
OK... so EVERYTHING as an option shifts left as to the only option for vasodilation on the LEFT SIDE of his picture, as the top option for vasodilation on the right is gone due to the virus filling ACE2 receptors.
At 8:03 As this shows, if someone has Ace inhibitors, that SHUTS DOWN ON THE LEFT SIDE ALAO even that option to go further with the Angiotensin I to Angiotension II. STOP. No more option to go further to even get to the options in the next step with Angiotensin II to go in the alternate paths of vasoconstriction/inflammation/fibrosis vs. vasodilator/anti-inflammatory/antifibrosis. The normal cascade options are all fouled up with NO options with an ACE inhibitor.
Having more angiotension II in the lungs vs. angiotension 1-7 causes a crazy reaction in the lungs.
I would go on.... but perhaps review and get to that point, and repost if you want me to go on? I know few here are interested in such, and don't want to bore... but to me, this is fascinating.. and so VERY SAD as that I think this disease is moving so fast, so many folks know this but there is not time to address and share to help others.
Me, I'm STAYING AT HOME as I have a health care directive which states SPECIFICALLY I will not be put on a ventilator.
Lemme know if you want to banter, or if others want me to continue, like this post.
NOTE: I haven't ventured into the bottom left options yet, and how angiotension blockers are good as wanted to ensure on board with what I said here.
MOO MOO MOO
@gitana1 who had questions on such earlier