Multisystem inflammatory syndrome in children (MIS-C and COVID-19)

[Yesiamapirate]

SC announces new case of MIS-C along with 1,346 new COVID-19 cases, 45 more deaths

"DHEC also announced another child in South Carolina has been diagnosed with Multisystem Inflammatory Syndrome in Children (MIS-C), which is associated with COVID-19. The child is between the ages of 10 and 17 and lives in the Upstate, where three other recent MIS-C cases have also been identified."

I just found this thread. Thank you for keeping track of he kids here. Breaks my heart.

 

[margarita25]

Dbm

 

[margarita25]

WHO / Multisystem inflammatory syndrome in children and adolescents temporally related to COVID-19
May 15
—-

Worrisome details noted in kids with COVID inflammatory syndrome
June 29, 2020
—

Studies find nearly 300 kids with inflammatory condition tied to Covid-19
June 29, 2020
—-

https://www.miamiherald.com/news/coronavirus/article243892967.html
July 1
—

"It's out there and it's occurring:" Clark County child has COVID related MIS-C
July 6
—-

The Latest on the Mysterious Inflammatory Syndrome in Children
July 7
—

Cardiac MRI Aids Evaluation of Children With Multisystem Inflammatory Syndrome (MIS-C) Associated With COVID-19
July 9
—-


Intensive care admissions of children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in the UK: a multicentre observational study
July 9
—-

First case of Multisystem Inflammatory Syndrome in children reported in Rappahannock Area Health District - Fredericksburg Today
July 10
—-

Multisystem inflammatory syndrome in children associated with COVID-19
July 13
—

Serology distinguishes children with MIS-C associated with COVID-19
July 13
—-

Doctors warn of rise in serious condition in Arizona kids from COVID-19 exposure
July 14
—-

Why Doctors Keep Monitoring Children Who Recover From Mysterious COVID-Linked Illness
July 15
—

AAP issues guidance on multisystem inflammatory syndrome in children
July 16
—-

CDC: 71% of MIS-C patients Hispanic or Black
July 16
—-

Identification of children at high-risk for MIS-C
July 17
—

Wisconsin coronavirus: 900 more COVID-19 cases, six kids with MIS-C
July 17
—-

Friday COVID-19 Roundup: 15 Cases of MIS-C in Kids, 2,885 New COVID Cases in L.A. County - SCVNews.com
July 17
—-

INTERVIEW: The MIS-C complication with children and COVID-19
July 17
—

AAP issues interim guidance for MIS-C
July 21
—

COVID-19’s Kawasaki-Like MIS-C Diagnosis Is Cropping Up in Adults
July 22
—-

https://www.nejm.org/doi/full/10.1056/NEJMoa2021680
July 23, 2020

Multisystem Inflammatory Syndrome in U.S. Children and Adolescents
List of authors.

• Leora R. Feldstein, Ph.D.,
• Erica B. Rose, Ph.D.,
• Steven M. Horwitz, M.D.,
• Jennifer P. Collins, M.D.,
• for the Overcoming COVID-19 Investigators, and the CDC COVID-19 Response Team*

July 23, 2020
N Engl J Med 2020; 383:334-346
DOI: 10.1056/NEJMoa2021680
—-

2 Colorado children die from coronavirus-related disease
July 23

2 Children In Colorado Die From MIS-C, Mysterious Syndrome Linked To Coronavirus
July 23

2 children have died in Colorado of MISC-C, rare syndrome tied to COVID-19 – The Denver Post
July 23

2 Colorado deaths attributed to multi-system inflammatory syndrome, the child disorder linked to coronavirus
July 23

“Dominguez cautioned that the CDC is casting a wide net as it investigates MIS-C and that some patients who are simply battling coronavirus and not necessarily the disorder in Colorado may be lumped together. He said, for instance, that Children’s had a child who died who met the CDC’s broad definition of MIS-C cases but that they were “somewhat atypical of kids that we are seeing with MIS-C.”

“There is a clinical definition and there is an epidemiological definition,” he said. “The CDC’s definition is pretty broad. There’s probably a few kids that meet the definition that probably have something that’s slightly different than what we’re currently thinking about what MIS-C probably is.”

Gov. Jared Polis and his public health team have encouraged Colorado parents to stay vigilant in case their children start showing signs of the disorder.“
—-

'He's hurting': Mom of teen with MIS-C details 2 month-long recovery
July 23
—-

SC announces 2 more cases of MIS-C in children; 1,538 new cases of COVID-19, 49 additional deaths
July 23
—

Beaufort Co. health officials speak about MIS-C, COVID-19 cases
July 24
—-

Nearly 2,000 additional coronavirus cases; 1 more case of MIS-C reported Friday
July 24
—-

8-year-old Florida boy hospitalized with illness caused by COVID
July 25
—-

73-percent of kids with mis-c were previously healthy, CDC says | KAMR - MyHighPlains.com
July 27
—

Cuomo on MIS-C: “The more you look for it, the more you find it"
July 28
—-

Higher COVID-19 rates seen in Black and Hispanic kids
July 29
—-

MIS-C different from severe COVID-19 in children: Findings show that MIS-C is a post-infectious syndrome distinct from Kawasaki disease and may help guide treatment decisions
July 30

CHOP researchers identify lab profiles that differentiate MIS-C from COVID-19 in children
July 30

CHOP Researchers Identify Lab Profiles that Differentiate MIS-C from COVID-19 in Children
July 30
—-

Upper Keys boy battling rare syndrome linked to COVID-19 - Florida Keys Weekly Newspapers
July 30
—-

Upstate child diagnosed with MIS-C associated with COVID-19, DHEC reports
July 31
—-

One new MIS-C case reported in SC, total now at five
July 31
—-

DHEC: 6th SC child diagnosed with MIS-C - ABC Columbia
July 31
—-

MIS-C's Impact on Children
July 31
—-

Duval County 16-year-old has rare disease linked to COVID-19
July 31
—-

MIS-C: Doctors make progress on COVID-related illness affecting kids
Aug 2
—

Local mother speaks out after son was diagnosed with Mis-C - KYMA
Aug 3
—-

As South Lake Tahoe boy fights for his life, dad wants officials to take COVID-19 more seriously
Aug 3
—-

Florida Keys boy leaves hospital after battling MIS-C, an effect of COVID-19
August 4, 2020
—

Tribe issues MIS-C warning for children
Aug 5
—

‘Be Strong:' 8-Year-Old Beats COVID-19, MIS-C Complications
Aug 6

Coronavirus News: 8-year-old boy who survived mystery illness linked to COVID-19 honored by hospital
Aug 6
—-

LDH reports 14 new cases, third child death from COVID-19-related illness MIS-C | WNTZ - cenlanow.com
Aug 6
—-

Goodyear baby survives rare illness linked to COVID-19
Aug 6
—-

Look for Neurologic Symptoms in Children with Multisystem... : Neurology Today
Aug 6
—-

Liam's road to recovery - KYMA
Aug 6
—-

Local teen beats Covid-19 and post viral syndrome
Aug 7

 

[margarita25]

NBC Nightly News Broadcast (Full) - August 7th, 2020 | NBC Nightly News

Above:

Kids and COVID: Misc-C: CDC reports 570 cases in 40 states through the end of July, 10 children have died in the US.

Obesity is mentioned.

 

[margarita25]

This article doesn’t mention MIS-C directly, but posting for reference:

97,000 children reportedly test positive for coronavirus in two weeks as schools gear up for instruction

“Nearly 100,000 children tested positive for the coronavirus in the last two weeks of July, a new report from the American Academy of Pediatrics finds. Just over 97,000 children tested positive for the coronavirus from July 16 to July 30, according to the association.

Out of almost 5 million reported COVID-19 cases in the U.S., CBS News' Michael George reports that the group found that more than 338,000 were children.”

[...]

“More than 25 children died of the coronavirus in July alone. Pressure to get kids back into the classroom has left superintendents in more than 13,000 different school districts across the country to figure out how to keep children safe amid a myriad of public health advisories, and handle learning differences.”

[...]

“"You're going to see a very clean and disinfected bus," Transportation Director Matt Miles said. "We actually have fogging machines."”

 

[10ofRods]

WHO / Multisystem inflammatory syndrome in children and adolescents temporally related to COVID-19
May 15
—-

Worrisome details noted in kids with COVID inflammatory syndrome
June 29, 2020
—

Studies find nearly 300 kids with inflammatory condition tied to Covid-19
June 29, 2020
—-

https://www.miamiherald.com/news/coronavirus/article243892967.html
July 1
—

"It's out there and it's occurring:" Clark County child has COVID related MIS-C
July 6
—-

The Latest on the Mysterious Inflammatory Syndrome in Children
July 7
—

Cardiac MRI Aids Evaluation of Children With Multisystem Inflammatory Syndrome (MIS-C) Associated With COVID-19
July 9
—-


Intensive care admissions of children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in the UK: a multicentre observational study
July 9
—-

First case of Multisystem Inflammatory Syndrome in children reported in Rappahannock Area Health District - Fredericksburg Today
July 10
—-

Multisystem inflammatory syndrome in children associated with COVID-19
July 13
—

Serology distinguishes children with MIS-C associated with COVID-19
July 13
—-

Doctors warn of rise in serious condition in Arizona kids from COVID-19 exposure
July 14
—-

Why Doctors Keep Monitoring Children Who Recover From Mysterious COVID-Linked Illness
July 15
—

AAP issues guidance on multisystem inflammatory syndrome in children
July 16
—-

CDC: 71% of MIS-C patients Hispanic or Black
July 16
—-

Identification of children at high-risk for MIS-C
July 17
—

Wisconsin coronavirus: 900 more COVID-19 cases, six kids with MIS-C
July 17
—-

Friday COVID-19 Roundup: 15 Cases of MIS-C in Kids, 2,885 New COVID Cases in L.A. County - SCVNews.com
July 17
—-

INTERVIEW: The MIS-C complication with children and COVID-19
July 17
—

AAP issues interim guidance for MIS-C
July 21
—

COVID-19’s Kawasaki-Like MIS-C Diagnosis Is Cropping Up in Adults
July 22
—-

https://www.nejm.org/doi/full/10.1056/NEJMoa2021680
July 23, 2020

Multisystem Inflammatory Syndrome in U.S. Children and Adolescents
List of authors.

• Leora R. Feldstein, Ph.D.,
• Erica B. Rose, Ph.D.,
• Steven M. Horwitz, M.D.,
• Jennifer P. Collins, M.D.,
• for the Overcoming COVID-19 Investigators, and the CDC COVID-19 Response Team*

July 23, 2020
N Engl J Med 2020; 383:334-346
DOI: 10.1056/NEJMoa2021680
—-

2 Colorado children die from coronavirus-related disease
July 23

2 Children In Colorado Die From MIS-C, Mysterious Syndrome Linked To Coronavirus
July 23

2 children have died in Colorado of MISC-C, rare syndrome tied to COVID-19 – The Denver Post
July 23

2 Colorado deaths attributed to multi-system inflammatory syndrome, the child disorder linked to coronavirus
July 23

“Dominguez cautioned that the CDC is casting a wide net as it investigates MIS-C and that some patients who are simply battling coronavirus and not necessarily the disorder in Colorado may be lumped together. He said, for instance, that Children’s had a child who died who met the CDC’s broad definition of MIS-C cases but that they were “somewhat atypical of kids that we are seeing with MIS-C.”

“There is a clinical definition and there is an epidemiological definition,” he said. “The CDC’s definition is pretty broad. There’s probably a few kids that meet the definition that probably have something that’s slightly different than what we’re currently thinking about what MIS-C probably is.”

Gov. Jared Polis and his public health team have encouraged Colorado parents to stay vigilant in case their children start showing signs of the disorder.“
—-

'He's hurting': Mom of teen with MIS-C details 2 month-long recovery
July 23
—-

SC announces 2 more cases of MIS-C in children; 1,538 new cases of COVID-19, 49 additional deaths
July 23
—

Beaufort Co. health officials speak about MIS-C, COVID-19 cases
July 24
—-

Nearly 2,000 additional coronavirus cases; 1 more case of MIS-C reported Friday
July 24
—-

8-year-old Florida boy hospitalized with illness caused by COVID
July 25
—-

73-percent of kids with mis-c were previously healthy, CDC says | KAMR - MyHighPlains.com
July 27
—

Cuomo on MIS-C: “The more you look for it, the more you find it"
July 28
—-

Higher COVID-19 rates seen in Black and Hispanic kids
July 29
—-

MIS-C different from severe COVID-19 in children: Findings show that MIS-C is a post-infectious syndrome distinct from Kawasaki disease and may help guide treatment decisions
July 30

CHOP researchers identify lab profiles that differentiate MIS-C from COVID-19 in children
July 30

CHOP Researchers Identify Lab Profiles that Differentiate MIS-C from COVID-19 in Children
July 30
—-

Upper Keys boy battling rare syndrome linked to COVID-19 - Florida Keys Weekly Newspapers
July 30
—-

Upstate child diagnosed with MIS-C associated with COVID-19, DHEC reports
July 31
—-

One new MIS-C case reported in SC, total now at five
July 31
—-

DHEC: 6th SC child diagnosed with MIS-C - ABC Columbia
July 31
—-

MIS-C's Impact on Children
July 31
—-

Duval County 16-year-old has rare disease linked to COVID-19
July 31
—-

MIS-C: Doctors make progress on COVID-related illness affecting kids
Aug 2
—

Local mother speaks out after son was diagnosed with Mis-C - KYMA
Aug 3
—-

As South Lake Tahoe boy fights for his life, dad wants officials to take COVID-19 more seriously
Aug 3
—-

Florida Keys boy leaves hospital after battling MIS-C, an effect of COVID-19
August 4, 2020
—

Tribe issues MIS-C warning for children
Aug 5
—

‘Be Strong:' 8-Year-Old Beats COVID-19, MIS-C Complications
Aug 6

Coronavirus News: 8-year-old boy who survived mystery illness linked to COVID-19 honored by hospital
Aug 6
—-

LDH reports 14 new cases, third child death from COVID-19-related illness MIS-C | WNTZ - cenlanow.com
Aug 6
—-

Goodyear baby survives rare illness linked to COVID-19
Aug 6
—-

Look for Neurologic Symptoms in Children with Multisystem... : Neurology Today
Aug 6
—-

Liam's road to recovery - KYMA
Aug 6
—-

Local teen beats Covid-19 and post viral syndrome
Aug 7

That, my friend, is a masterpiece. Thank you.

 

[margarita25]

CDC:
Coronavirus Disease 2019 (COVID-19)

Care for Children
Updated Aug. 17, 2020

Summary of Recent Changes
Revisions were made on August 14, 2020 to reflect new evidence about COVID-19 in children.

 

[anneg]

Multisystem Inflammatory Syndrome in Children (MIS-C)
This report is updated on the first and third Friday of each month.

Health Department-Reported Cases of Multisystem Inflammatory Syndrome in Children (MIS-C) in the United States

As of 8/20/2020, CDC has received reports of 694 confirmed cases of MIS-C and 11 deaths in 42 states, New York City, and Washington, DC. Additional cases are under investigation.

• Most cases are in children between the ages of 1 and 14 years, with an average age of 8 years.
• Cases have occurred in children from <1 year old to 20 years old.
• More than 70% of reported cases have occurred in children who are Hispanic/Latino (239 cases) or Non-Hispanic Black (197 cases).
• 99% of cases (687) tested positive for SARS CoV-2, the virus that causes COVID-19. The remaining 1% were around someone with COVID-19.
• Most children developed MIS-C 2-4 weeks after infection with SARS-CoV-2.
• Slightly more than half (55%) of reported cases were male.

(SNIP)

Next steps
Children appeared to be less likely than adults to be infected or to have severe illness early in the COVID-19 pandemic; however, as the outbreak has progressed, larger numbers of children are getting infected. It’s unknown whether this increase in COVID-19 cases among children will also increase cases of MIS-C. CDC and state partners will be monitoring for additional cases and will adapt MIS-C recommendations as needed.

CDC investigators are assessing reported cases and children’s health outcomes to try to learn more about specific risk factors for MIS-C, how the illness progresses in children, and how to better identify MIS-C and distinguish it from similar illnesses.

Case Definition for Multisystem Inflammatory Syndrome in Children (MIS-C)

• An individual aged <21 years presenting with feveri, laboratory evidence of inflammationii, and evidence of clinically severe illness requiring hospitalization, with multisystem (>2) organ involvement (cardiac, renal, respiratory, hematologic, gastrointestinal, dermatologic or neurological); AND
• No alternative plausible diagnoses; AND
• Positive for current or recent SARS-CoV-2 infection by RT-PCR, serology, or antigen test; or COVID-19 exposure within the 4 weeks prior to the onset of symptoms

iFever >38.0°C for ≥24 hours, or report of subjective fever lasting ≥24 hours
iiIncluding, but not limited to, one or more of the following: an elevated C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), fibrinogen, procalcitonin, d-dimer, ferritin, lactic acid dehydrogenase (LDH), or interleukin 6 (IL-6), elevated neutrophils, reduced lymphocytes and low albumin

Additional comments

• Some individuals may fulfill full or partial criteria for Kawasaki disease but should be reported if they meet the case definition for MIS-C
• Consider MIS-C in any pediatric death with evidence of SARS-CoV-2 infection

 

[ZoriahNZ]

Post-COVID syndrome severely damages children’s hearts; 'immense inflammation’ causing cardiac blood vessel dilation - UT Health San Antonio

Multisystem inflammatory syndrome in children (MIS-C), believed to be linked to COVID-19, damages the heart to such an extent that some children will need lifelong monitoring and interventions, said the senior author of a medical literature review published Sept. 4 in EClinicalMedicine, a journal of The Lancet.

Those poor children.

 

[margarita25]

CDC /
Weekly / August 14, 2020 / 69(32);1074–1080
On August 7, 2020, this report was posted online as an MMWR Early Release.


COVID-19–Associated Multisystem Inflammatory Syndrome in Children — United States, March–July 2020 | MMWR

 

[margarita25]

Behind the White House Effort to Pressure the C.D.C. on School Openings

(Link courtesy of 10@rods)

 

[margarita25]

CDC identifies new Covid-19 syndrome in adults similar to MIS-C in kids - CNN

“They're calling it multisystem inflammatory syndrome in adults, or MIS-A, and say it's similar to multisystem inflammatory syndrome in children or MIS-C. Like MIS-C, MIS-A is not obviously linked to coronavirus and sufferers may not show any other symptoms that would point to Covid-19 infection.
But MIS-A has killed at least three patients and, similar to Covid-19, disproportionately hits racial and ethnic minorities, the CDC team said.“

 

[10ofRods]

New studies from India show that children do get CoVid at the same rates as any one else - and, based on their size, they also spread it (they're not as tall as the best spreaders - and they don't have the lung capacity of athletes, but they spread roughly as much as adults).

The studies are on the ground, empirical and very large compared to most others. India also has some natural social distancing built in (high caste people doing way better than low caste people - and almost no low caste people were living to be past 60 anyway).

 

[BetteDavisEyes]

A rare Covid-19 complication was reported in children. Now, it's showing up in adults.

"This needs to be in the forefront of every intensive care unit physician's mind," said one expert.

It was a rash that tipped Dr. Alisa Femia off.

Femia, director of inpatient dermatology at NYU Langone Health in New York City, was looking at a patient's chart, which included several photos of the 45-year-old man who had, in recent weeks, cared for his wife while she was sick with Covid-19. The man had dusky-red circular patches on the palms of his hands and the soles of his feet. His eyes were pink, and his lips were extremely chapped.

His body was erupting with the kind of extreme inflammation noted almost exclusively in children at the time.

"Before I even saw the patient," Femia recalled, "I said: 'This hasn't been reported yet. This must be MIS-A.'"...

 

[margarita25]

Colorado resident, 20, with ‘mild’ coronavirus case later develops rare condition: officials

“A 20-year-old Colorado resident who battled the novel coronavirus later developed a rare but serious condition known as multisystem inflammatory syndrome (MIS-C), according to local health officials in the state.”

[...]

“Since the pandemic began, there have been various reports of multisystem inflammatory syndrome, but most cases have occurred in children, which is known as MIS-C.“

[...]

“However, earlier this month, the Centers for Disease Control and Prevention (CDC)identified the condition among adults, drawing on reports of 27 adult patients to describe a new, similar condition known as multisystem inflammatory syndrome in adults (MIS-A).

“Findings indicate that adult patients of all ages with current or previous SARS-CoV-2 infection can develop a hyperinflammatory syndrome resembling MIS-C,” the authors wrote at the time, adding that measures to limit COVID-19 spread may help prevent MIS-A.“

 

[margarita25]

Child Covid-19 cases increased 14% says AAP, with close to 800,000 US kids infected - CNN
Oct 27, 2020

(Link courtesy of @ZoriahNZ)

 

[margarita25]

Mayo Clinic / Updated Oct 8:
Multisystem inflammatory syndrome in children (MIS-C) and COVID-19 - Symptoms and causes

 

[margarita25]

Wichita Doctors Diagnose First Case Of MIS-C, A Condition That Stems From COVID-19
12 hours ago

 

[margarita25]

Study highlights overlapping symptoms of MIS-C, other illnesses

 

[margarita25]

‘We don’t know why this happens’: When to suspect MIS-C in a patient