Coronavirus COVID-19 - Global Health Pandemic #31

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“But why does the disease transfer in the first place? That answer seems simpler, says Cunningham, and it involves an alien phrase that we will have to get used to, as it is one that has changed our lives -- "zoonotic spillover" or transfer.
"The underlying causes of zoonotic spillover from bats or from other wild species have almost always -- always -- been shown to be human behavior," said Cunningham. "Human activities are causing this."
When a bat is stressed -- by being hunted, or having its habitat damaged by deforestation -- its immune system is challenged and finds it harder to cope with pathogens it otherwise took in its stride. "We believe that the impact of stress on bats would be very much as it would be on people," said Cunningham.
"It would allow infections to increase and to be excreted -- to be shed. You can think of it like if people are stressed and have the cold sore virus, they will get a cold sore. That is the virus being 'expressed.' This can happen in bats too.

In the likely epicenter of the virus -- the so-called wet-markets of Wuhan, China -- where wild animals are held captive together and sold as delicacies or pets, a terrifying mix of viruses and species can occur.
"If they are being shipped or held in markets, in close proximity to other animals or humans," said Cunningham, "then there is a chance those viruses are being shed in large numbers." He said the other animals in a market like that are also more vulnerable to infection as they too are stressed.
"We are increasing transport of animals -- for medicine, for pets, for food -- at a scale that we have never done before," said Kate Jones, Chair of Ecology and Biodiversity at University College London.
"We are also destroying their habitats into landscapes that are more human-dominated. Animals are mixing in weird ways that have never happened before. So in a wet market, you are going to have a load of animals in cages on top of each other."”

-more at link

I hope factory farmers are watching all this carefully moo.
I don't know if this doctor of infectious diseases is correct or not, but he claims if all people were vegetarians, there wouldn't be any pandemics. The problem for pandemics is that people and animals live so close together.
Professorn: Inga pandemier om alla hade varit vegetarianer
 
Fifth colleague of China's coronavirus whistle-blower doctor 'dies of the disease' | Daily Mail Online

Fifth colleague of China's coronavirus whistle-blower 'dies of the disease' as late doctor who sounded the alarm of the outbreak is pardoned by police

Liu Li, an archive manager of Wuhan Central Hospital, lost his life to the killer bug today at the age of 45, according to a report.




    • The news comes after Wuhan police retracted their letter of punishment to Dr Li Wenliang

    • The report of Liu's death comes after police in Wuhan police retracted the letter of oral punishment which they issued to 34-year-old Dr Li on January 3 and apologised to the public over the matter
 
“But why does the disease transfer in the first place? That answer seems simpler, says Cunningham, and it involves an alien phrase that we will have to get used to, as it is one that has changed our lives -- "zoonotic spillover" or transfer.
"The underlying causes of zoonotic spillover from bats or from other wild species have almost always -- always -- been shown to be human behavior," said Cunningham. "Human activities are causing this."
When a bat is stressed -- by being hunted, or having its habitat damaged by deforestation -- its immune system is challenged and finds it harder to cope with pathogens it otherwise took in its stride. "We believe that the impact of stress on bats would be very much as it would be on people," said Cunningham.
"It would allow infections to increase and to be excreted -- to be shed. You can think of it like if people are stressed and have the cold sore virus, they will get a cold sore. That is the virus being 'expressed.' This can happen in bats too.

In the likely epicenter of the virus -- the so-called wet-markets of Wuhan, China -- where wild animals are held captive together and sold as delicacies or pets, a terrifying mix of viruses and species can occur.
"If they are being shipped or held in markets, in close proximity to other animals or humans," said Cunningham, "then there is a chance those viruses are being shed in large numbers." He said the other animals in a market like that are also more vulnerable to infection as they too are stressed.
"We are increasing transport of animals -- for medicine, for pets, for food -- at a scale that we have never done before," said Kate Jones, Chair of Ecology and Biodiversity at University College London.
"We are also destroying their habitats into landscapes that are more human-dominated. Animals are mixing in weird ways that have never happened before. So in a wet market, you are going to have a load of animals in cages on top of each other."”

-more at link

I hope factory farmers are watching all this carefully moo.
That article mentions "When they fly they have a peak body temperature that mimics a fever," said Andrew Cunningham, Professor of Wildlife Epidemiology at the Zoological Society of London. "It happens at least twice a day with bats -- when they fly out to feed and then they return to roost. And so the pathogens that have evolved in bats have evolved to withstand these peaks of body temperature."

I'm not understanding, because they fly around all night feeding, why would their temp be higher only when they leave the roost to feed. Researcher says "at least" but still I don't understand, unless they were quite cool in the roost and generate a sudden burst of heat when they fly out at dusk, more than they would generate just flying/feeding. Anyway, because they do have the high temps twice a day, that means our own human fevers don't kill the virus.
 
Dear @Tillicum,

Yes, your Governor has been superb during a time like this!

Accurate and practical information, given in a way that is understanding to everyone. This is so comforting to listen to leaders such as Governor DeWine and Governor Cuomo. I'm sure there are others - I'm just not familiar with their names.
Here are a few worth mentioning.

Governor Murphy (NJ), Governor Wolf (PA), Governor Lamont (CT) and now Governor Carney (DE) have pledged to work together and play follow the leader with these "crackdowns."
 
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I spoke to a NP last night. She told me about a study on the use of N-acetylcysteine (among other nutraceuticals) to control coronavirus and I thought I would share the study with you guys.

Nutraceuticals have potential for boosting the type 1 interferon response to RNA viruses including influenza and coronavirus - ScienceDirect

Mucomyst had been used in respiratory care forever. ( N-actetyl cysteine or NAC)
Mucomyst - FDA prescribing information, side effects and uses

There is nothing new about this. It's given by nebulizer. Because of the pathologic effects of COVID-19 on the pulmonary tissue, NAC is not going to help the severe pulmonary problems. It may actually contribute to the problem.

And it does not cure cancer, as some homeopathic practitioners have claimed. And it is does not work as a mucolytic agent when consumed in pill form. Do not buy this thinking it's going to do any good in pill form.
 
I spoke to a NP last night. She told me about a study on the use of N-acetylcysteine (among other nutraceuticals) to control coronavirus and I thought I would share the study with you guys.

Nutraceuticals have potential for boosting the type 1 interferon response to RNA viruses including influenza and coronavirus - ScienceDirect

Wow, that's great!! Thanks for the tip - I've got half of a sizeable bottle of N-AC here already; and I also found the giant backup bottle of Costco Mucinex I knew I had, as well as some melatonin, in the search; so here's hoping I get more sleep and a stronger immune system. ;)
 
You have to watch this video about an Italian hospital to see what WE could be facing if we cannot control this or squash the curve:


This one has room after room full of patients on guerney's with some sorts of breathing apparatus. And they are lying in beds in a hallway, or they are in wheelchairs. There must be 40 incapacitated people and you only see 2 caregivers present.

This is what the US may be facing, or worse!!!!

That is heart breaking. They all look so ill
 
Chloroquine is not a miracle drug.

It is an old old drug that is losing efficacy in much of the world, in combating specific types of malaria.

And it is a nasty drug to take, with very unpleasant side effects that make it poorly tolerated as an anti-malarial drug for long term use

I'm glad Dr. Faucci keeps stepping in to correct the non-medical enthusiasm about it's use.

Here are a list of it's side effects:

  • attempts at killing oneself
  • back, leg, or stomach pains
  • black, tarry stools
  • bleeding gums
  • blistering, peeling, or loosening of the skin
  • blood in the urine or stools
  • blurred or decreased vision
  • change in near or distance vision
  • chest discomfort or pain
  • chills
  • cold sweats
  • confusion
  • continuing ringing or buzzing or other unexplained noise in the ears
  • cough
  • dark urine
  • difficulty in focusing the eyes
  • difficulty with speaking
  • difficulty with swallowing
  • disturbed color perception
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • double vision
  • fast, slow, irregular, or pounding heartbeat
  • feeling that others are watching you or controlling your behavior
  • feeling that others can hear your thoughts
  • feeling, seeing, or hearing things that are not there
  • fever
  • general tiredness and weakness
  • halos around lights
  • inability to move the eyes
  • increased blinking or spasms of the eyelid
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • light-colored stools
  • lower back or side pain
  • muscle trembling, jerking, or stiffness
  • muscular pain, tenderness, wasting, or weakness
  • night blindness
  • overbright appearance of lights
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • restlessness
  • shuffling walk
  • sores, ulcers, or white spots on the lips or in the mouth
  • sticking out of the tongue
  • stiffness of the limbs
  • sweating
  • swollen or painful glands
  • tightness in the chest
  • trouble breathing
  • tunnel vision
  • twitching, twisting, or uncontrolled repetitive movements of the tongue, lips, face, arms, or legs
  • uncontrolled movements, especially of the face, neck, and back
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • upper right abdominal or stomach pain
  • yellow eyes and skin
Good Lord!!
 
"Expert recommendations about wearing masks in public, however, have changed as the US’s case count surpassed 14,000 by mid-March, with some Covid-19 patients being asymptomatic or only exhibiting mild symptoms. Shan Soe-Lin and Robert Hecht of the nonprofit Pharos Global Health Advisors published an op-ed in the Boston Globe on March 19 writing, “Masks work. There is widespread evidence from the field of occupational health, the SARS epidemic, and other outbreaks that wearing masks protects us from germs and interrupts the transmission of disease from sick to healthy people.” They suggested for the average person to cover their face with nonmedical masks when leaving the house, using accessories like bandanas or scarves."
Health care workers are calling on people to donate face masks
 
DH had Malaria in 2006, after a dive trip to Roatan, Honduras. We went on a zip tour through the jungle. I wore bug spray, he did not. He spent five days in ICU.

He was give chloroquine, along with many other drugs, including morphine. Malaria is a very painful parasite.

Luckily, he experienced none of the possible side effects.

His doc was an infectious disease specialist from India. Perhaps dosing is tricky.

He was a very popular patient. Most hospitals in Minnesota never treat Malaria.

The malaria prevalent in Honduras and central America is Plasmodium vivax, which is currently Chloroquine-sensitive.

Most of the rest of the world has Cloroquine-resistant Plasmodium strains.
 
That is heart breaking. They all look so ill

I know. My heart breaks to think that most of those people are either dead now or dying.

And it's just hospital ward after hospital ward full of nothing but COVID-19 patients, most of whom seem non-responsive

The ones in the hall seem less affected, but it's a horribly grim scene
 
Mucomyst had been used in respiratory care forever. ( N-actetyl cysteine or NAC)
Mucomyst - FDA prescribing information, side effects and uses

There is nothing new about this. It's given by nebulizer. Because of the pathologic effects of COVID-19 on the pulmonary tissue, NAC is not going to help the severe pulmonary problems. It may actually contribute to the problem.

And it does not cure cancer, as some homeopathic practitioners have claimed. And it is does not work as a mucolytic agent when consumed in pill form. Do not buy this thinking it's going to do any good in pill form.

I wonder why it helped the people in the study
 
Wow, that's great!! Thanks for the tip - I've got half of a sizeable bottle of N-AC here already; and I also found the giant backup bottle of Costco Mucinex I knew I had, as well as some melatonin, in the search; so here's hoping I get more sleep and a stronger immune system. ;)

I happened to have some on hand as well :)
 
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