Family trip to New Orleans several years ago, trip there we made an overnight stop in Atlanta. On our return trip we left in the early afternoon, ~3pm. Total trip distance is ~840 miles. We made one stop for dinner and then I drove throughout the night and early morning.
On a business trip to Birmingham, Al ended up being an all nighter followed by business meeting and all day of work. Flight was to leave at 6pm from RDU to Atl to BHM. Flight from RDU delayed and we arrived in ATL around 4am. There was no connecting flight to BHM that would get us to the meeting on time, so we rented a car. Although the drive is just 240 miles there was a severe storm which caused us to drive ~40mph for a majority of the trip. We arrived slightly ahead of time for 10am meeting, meeting lasted 1 hour and then we were in the lab working with the customer for the duration of the workday.
Only point to these ramblings is that the driving of JY was quite doable.